PMID- 4030587
OWN - NLM
STAT- MEDLINE
DCOM- 19851021
LR  - 20171213
IS  - 8750-7587 (Print)
IS  - 0161-7567 (Linking)
VI  - 59
IP  - 2
DP  - 1985 Aug
TI  - Differences in endogenous pyrogen fevers induced by iv and icv routes in rabbits.
PG  - 342-7
AB  - We have compared the characteristics of fevers produced by endogenous pyrogen 
      administered by the intravenous (iv) and by the intracerebroventricular (icv) 
      routes in conscious rabbits. Fevers induced by the intracerebroventricular route 
      have a longer latency to onset, a less steep rise in body temperature, and a 
      longer time to peak elevation in body temperature than do fevers induced by the 
      intravenous route. Furthermore, a dose of indomethacin (2 mg/kg) administered 
      intravenously, which is effective in markedly attenuating fevers produced by the 
      intravenous route, was completely without effect on fevers induced by the 
      intracerebroventricular route. On the other hand, when indomethacin (500 
      micrograms) was infused intracerebroventricularly, it markedly reduced fevers 
      induced by the subsequent injection of endogenous pyrogen into the contralateral 
      cerebral ventricle, but such pretreatment had little effect on fevers elicited by 
      intravenous injections of endogenous pyrogen. It is concluded that the sites of 
      action of endogenous pyrogen in response to intravenous injections of pyrogen are 
      different from those responding to intracerebroventricular injections of pyrogen 
      and that this is manifest in several distinct differences in the characteristics 
      of the two fevers. These results indicate that the intracerebroventricular model 
      of fever production is not appropriate for the study of the normal pathogenesis 
      of fever.
FAU - Stitt, J T
AU  - Stitt JT
FAU - Bernheim, H A
AU  - Bernheim HA
LA  - eng
GR  - NS-11487/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Appl Physiol (1985)
JT  - Journal of applied physiology (Bethesda, Md. : 1985)
JID - 8502536
RN  - 0 (Interleukin-1)
RN  - 0 (Proteins)
RN  - 0 (leukocyte endogenous mediator)
RN  - XXE1CET956 (Indomethacin)
SB  - IM
MH  - Animals
MH  - Fever/physiopathology
MH  - Indomethacin/pharmacology
MH  - Injections, Intravenous
MH  - Injections, Intraventricular
MH  - *Interleukin-1
MH  - Male
MH  - Proteins/*administration & dosage/antagonists & inhibitors
MH  - Rabbits
EDAT- 1985/08/01 00:00
MHDA- 1985/08/01 00:01
CRDT- 1985/08/01 00:00
PHST- 1985/08/01 00:00 [pubmed]
PHST- 1985/08/01 00:01 [medline]
PHST- 1985/08/01 00:00 [entrez]
AID - 10.1152/jappl.1985.59.2.342 [doi]
PST - ppublish
SO  - J Appl Physiol (1985). 1985 Aug;59(2):342-7. doi: 10.1152/jappl.1985.59.2.342.