PMID- 4038814
OWN - NLM
STAT- MEDLINE
DCOM- 19850325
LR  - 20190908
IS  - 0036-553X (Print)
IS  - 0036-553X (Linking)
VI  - 34
IP  - 2
DP  - 1985 Feb
TI  - The kinetics of short-lived indium-111 radiolabelled platelets.
PG  - 137-45
AB  - We have studied the kinetics of autologous 111In-labelled platelets in patients 
      with reduced platelet life span (less than 4.5 d), most of whom were 
      thrombocytopenic, and of homologous 111In-labelled platelets in patients with 
      severe thrombocytopenia. Intrasplenic platelet transit time (t) was calculated by 
      compartmental and deconvolution analysis. In patients with a mean platelet life 
      span of less than a few h, compartmental analysis may not be valid and so only 
      deconvolution analysis was applied. There was a close correlation between values 
      of t given by the two approaches (r = 0.88, n = 18, P less than 0.001). In some 
      patients with severely reduced mean platelet life span (MPLS), the deconvolved 
      splenic platelet clearance curves appeared to approach an asymptote, the relative 
      magnitude of which was indicative of the irreversible extraction fraction by the 
      spleen of incoming platelets. In other patients with severely reduced MPLS 
      resulting from abnormal intra-hepatic platelet destruction, the deconvolved 
      splenic curves resembled the normal. The intrasplenic platelet transit time 
      showed no clear relationship with other parameters. It was concluded that 
      platelet pooling within the spleen is normal in patients with reduced platelet 
      life span, including idiopathic thrombocytopenic purpura, even when the 
      predominant site of destruction is the spleen, and that platelets are not delayed 
      in transit through the spleen in preparation for their removal from the 
      circulation and ultimate destruction.
FAU - Peters, A M
AU  - Peters AM
FAU - Saverymuttu, S H
AU  - Saverymuttu SH
FAU - Bell, R N
AU  - Bell RN
FAU - Lavender, J P
AU  - Lavender JP
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Denmark
TA  - Scand J Haematol
JT  - Scandinavian journal of haematology
JID - 0404507
RN  - 0 (Radioisotopes)
RN  - 045A6V3VFX (Indium)
SB  - IM
MH  - Blood Platelets/metabolism/*physiology
MH  - Cell Movement
MH  - Cell Survival
MH  - Humans
MH  - *Indium
MH  - Kinetics
MH  - Liver/cytology
MH  - Purpura, Thrombocytopenic/blood
MH  - *Radioisotopes
MH  - Spleen/cytology/physiology
EDAT- 1985/02/01 00:00
MHDA- 1985/02/01 00:01
CRDT- 1985/02/01 00:00
PHST- 1985/02/01 00:00 [pubmed]
PHST- 1985/02/01 00:01 [medline]
PHST- 1985/02/01 00:00 [entrez]
AID - 10.1111/j.1600-0609.1985.tb02246.x [doi]
PST - ppublish
SO  - Scand J Haematol. 1985 Feb;34(2):137-45. doi: 10.1111/j.1600-0609.1985.tb02246.x.