PMID- 4040826 OWN - NLM STAT- MEDLINE DCOM- 19851015 LR - 20190824 IS - 0305-1870 (Print) IS - 0305-1870 (Linking) VI - 12 IP - 3 DP - 1985 May-Jun TI - Retarded development of hypertension in stroke-prone spontaneously hypertensive rats following chronic alcohol consumption. PG - 273-7 AB - The influence of chronic alcohol consumption on blood pressure was examined in normotensive Wistar/Kyoto rats (WKY) and in stroke-prone spontaneously hypertensive rats (SHR-SP). Ethanol, administered in drinking water from 5 weeks of age to produce moderate blood alcohol levels, substantially retarded the development of hypertension in SHR-SP and caused a mild reduction of blood pressure in WKY. Alcohol withdrawal caused an acute rise in blood pressure in both strains, followed by a reduction to the subnormal levels previously induced by alcohol treatment. This sustained antihypertensive effect of alcohol was not attributable to reductions of body weight or fluid intake. FAU - Howe, P R AU - Howe PR FAU - Rogers, P F AU - Rogers PF FAU - Smith, R M AU - Smith RM LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - Australia TA - Clin Exp Pharmacol Physiol JT - Clinical and experimental pharmacology & physiology JID - 0425076 RN - 3K9958V90M (Ethanol) SB - IM MH - Animals MH - Blood Pressure/*drug effects MH - Body Weight/drug effects MH - Ethanol/*pharmacology MH - Humans MH - Hypertension/*physiopathology MH - Male MH - Rats MH - Rats, Inbred SHR MH - Rats, Inbred WKY MH - Substance Withdrawal Syndrome/physiopathology EDAT- 1985/05/01 00:00 MHDA- 1985/05/01 00:01 CRDT- 1985/05/01 00:00 PHST- 1985/05/01 00:00 [pubmed] PHST- 1985/05/01 00:01 [medline] PHST- 1985/05/01 00:00 [entrez] AID - 10.1111/j.1440-1681.1985.tb02646.x [doi] PST - ppublish SO - Clin Exp Pharmacol Physiol. 1985 May-Jun;12(3):273-7. doi: 10.1111/j.1440-1681.1985.tb02646.x.