PMID- 4040998
OWN - NLM
STAT- MEDLINE
DCOM- 19851009
LR  - 20190701
IS  - 0024-3205 (Print)
IS  - 0024-3205 (Linking)
VI  - 37
IP  - 10
DP  - 1985 Sep 9
TI  - Adenylate cyclase activity and motor behavior following cerebral ischemia in the 
      unanesthetized gerbil.
PG  - 937-43
AB  - Five minutes of bilateral carotid occlusion in unanesthetized gerbils produced 
      substantial changes in spontaneous locomotor activity. Behavior was decreased 
      after 1 hr of reperfusion and was increased at 24 hrs post-ischemia. Adenylate 
      cyclase activity was measured in homogenates of frontal cortex and hippocampus at 
      90 min and 24 hrs following 5 min of cerebral ischemia. Enzyme activity was 
      determined in the absence and presence of the activators 
      guanosine-5'-triphosphate (GTP), guanylyl-5'-imidodiphosphate (GppNHp), 
      isoproterenol (Iso) plus GTP, and forskolin (Fors) plus GTP. Homogenates 
      responded with expected increases over basal adenylate cyclase activity with 
      addition of all activators. An additional small increase in 
      isoproterenol-stimulated activity was observed in frontal cortex homogenates at 
      90 min post-ischemia. No other significant changes in adenylate cyclase activity 
      were observed after either 90 min or 24 hrs of reperfusion. The substantial 
      increases in locomotor activity evident at 24 hrs after transient ischemia are 
      not associated with measurable changes in adenylate cyclase activity in 
      homogenates of frontal cortex or hippocampus.
FAU - Chandler, M J
AU  - Chandler MJ
FAU - Hornbrook, K R
AU  - Hornbrook KR
FAU - Carney, J M
AU  - Carney JM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - Netherlands
TA  - Life Sci
JT  - Life sciences
JID - 0375521
RN  - 0 (Diterpenes)
RN  - 1F7A44V6OU (Colforsin)
RN  - 34273-04-6 (Guanylyl Imidodiphosphate)
RN  - 86-01-1 (Guanosine Triphosphate)
RN  - EC 4.6.1.1 (Adenylyl Cyclases)
RN  - L628TT009W (Isoproterenol)
SB  - IM
MH  - Adenylyl Cyclases/*metabolism
MH  - Animals
MH  - Carotid Arteries
MH  - Cerebral Cortex/enzymology
MH  - Colforsin
MH  - Diterpenes/pharmacology
MH  - Gerbillinae
MH  - Guanosine Triphosphate/pharmacology
MH  - Guanylyl Imidodiphosphate/pharmacology
MH  - Hippocampus/enzymology
MH  - Ischemic Attack, Transient/*physiopathology
MH  - Isoproterenol/pharmacology
MH  - Ligation
MH  - Male
MH  - *Motor Activity
MH  - Time Factors
EDAT- 1985/09/09 00:00
MHDA- 1985/09/09 00:01
CRDT- 1985/09/09 00:00
PHST- 1985/09/09 00:00 [pubmed]
PHST- 1985/09/09 00:01 [medline]
PHST- 1985/09/09 00:00 [entrez]
AID - 0024-3205(85)90530-2 [pii]
AID - 10.1016/0024-3205(85)90530-2 [doi]
PST - ppublish
SO  - Life Sci. 1985 Sep 9;37(10):937-43. doi: 10.1016/0024-3205(85)90530-2.