PMID- 4043224
OWN - NLM
STAT- MEDLINE
DCOM- 19851121
LR  - 20190624
IS  - 0014-2999 (Print)
IS  - 0014-2999 (Linking)
VI  - 114
IP  - 2
DP  - 1985 Aug 15
TI  - Bombesin stimulates small intestinal motility after intracerebroventricular 
      administration to rats.
PG  - 167-73
AB  - The frequency and amplitude of contractions occurring in the duodenum and the 
      jejunum of freely-moving, unanesthetized, female Sprague-Dawley rats were 
      determined by continuously recording intestinal intraluminal pressure. 
      Intracerebroventricular (i.c.v.) administration of saline did not significantly 
      alter the frequency of contractions in either small bowel region when compared 
      with activity observed during a preinjection control period. I.c.v. 
      administration of bombesin (0.1-10 micrograms) produced a dose-related increase 
      in the frequency of duodenal contractions of up to 583% of control. While an 
      increase in jejunal motility was consistently seen with doses of 1 and 10 
      micrograms, the lowest bombesin dose tested (0.1 microgram) produced a 
      significant decrease in the frequency of contractions in this intestinal area. 
      The intestinal motor effects were seen within the first 30 min after the peptide, 
      and lasted for at least 1 h. Intraperitoneal administration of bombesin, at doses 
      200 times higher than those given centrally, failed to significantly alter 
      intestinal motility at either recording site. Whether all of the complex 
      intestinal motor effects of bombesin can be directly related to its centrally 
      initiated inhibitory transit effect is unclear; however, the stimulation of 
      contraction frequency in the duodenum at all doses tested suggest that the 
      antitransit effects of bombesin may be, in part, the result of either an increase 
      in the frequency of non-propulsive contractions or a disruption of the normal 
      coordinated propulsive motility pattern of the duodenum.
FAU - Porreca, F
AU  - Porreca F
FAU - Fulginiti, J T
AU  - Fulginiti JT
FAU - Burks, T F
AU  - Burks TF
LA  - eng
GR  - DA 02163/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - Eur J Pharmacol
JT  - European journal of pharmacology
JID - 1254354
RN  - PX9AZU7QPK (Bombesin)
SB  - IM
MH  - Animals
MH  - Bombesin/administration & dosage/*pharmacology
MH  - Dose-Response Relationship, Drug
MH  - Female
MH  - Gastrointestinal Motility/*drug effects
MH  - Injections, Intraventricular
MH  - Muscle Contraction/drug effects
MH  - Muscle, Smooth/drug effects
MH  - Rats
MH  - Rats, Inbred Strains
EDAT- 1985/08/15 00:00
MHDA- 1985/08/15 00:01
CRDT- 1985/08/15 00:00
PHST- 1985/08/15 00:00 [pubmed]
PHST- 1985/08/15 00:01 [medline]
PHST- 1985/08/15 00:00 [entrez]
AID - 0014-2999(85)90624-7 [pii]
AID - 10.1016/0014-2999(85)90624-7 [doi]
PST - ppublish
SO  - Eur J Pharmacol. 1985 Aug 15;114(2):167-73. doi: 10.1016/0014-2999(85)90624-7.