PMID- 4043225
OWN - NLM
STAT- MEDLINE
DCOM- 19851121
LR  - 20190624
IS  - 0014-2999 (Print)
IS  - 0014-2999 (Linking)
VI  - 114
IP  - 2
DP  - 1985 Aug 15
TI  - Cross-tolerance between morphine- and bombesin-induced inhibition of intestinal 
      transit in rats.
PG  - 175-80
AB  - Intracerebroventricular (i.c.v.) injection of either morphine or bombesin to rats 
      inhibits intestinal transit of an intraduodenally administered radiochromium 
      marker. In this work, we show that tolerance develops to this effect of bombesin 
      after i.c.v. infusion of the peptide (0.5 micrograms/h for 4 days via an s.c. 
      implanted Alzet 2001 osmotic minipump). Tolerance also develops to the inhibition 
      of intestinal transit associated with i.c.v. morphine after s.c. injections of 
      morphine. Bombesin-induced delay of transit is not attenuated by naltrexone (10 
      mg/kg, s.c.), a standard narcotic antagonist. Nevertheless, two-way 
      cross-tolerance develops between bombesin and morphine in this system. This is a 
      surprising result since both bombesin and morphine are believed to act on 
      different receptors and cause opposite effects on intestinal motility in rats.
FAU - Gmerek, D E
AU  - Gmerek DE
FAU - Ryan, J P
AU  - Ryan JP
FAU - Cowan, A
AU  - Cowan A
LA  - eng
GR  - S07 RR05417/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - Eur J Pharmacol
JT  - European journal of pharmacology
JID - 1254354
RN  - 36B82AMQ7N (Naloxone)
RN  - 5S6W795CQM (Naltrexone)
RN  - 76I7G6D29C (Morphine)
RN  - PX9AZU7QPK (Bombesin)
SB  - IM
MH  - Animals
MH  - Bombesin/*pharmacology
MH  - Drug Tolerance
MH  - Gastrointestinal Motility/*drug effects
MH  - Male
MH  - Morphine/*pharmacology
MH  - Naloxone/pharmacology
MH  - Naltrexone/pharmacology
MH  - Rats
MH  - Rats, Inbred Strains
EDAT- 1985/08/15 00:00
MHDA- 1985/08/15 00:01
CRDT- 1985/08/15 00:00
PHST- 1985/08/15 00:00 [pubmed]
PHST- 1985/08/15 00:01 [medline]
PHST- 1985/08/15 00:00 [entrez]
AID - 0014-2999(85)90625-9 [pii]
AID - 10.1016/0014-2999(85)90625-9 [doi]
PST - ppublish
SO  - Eur J Pharmacol. 1985 Aug 15;114(2):175-80. doi: 10.1016/0014-2999(85)90625-9.