PMID- 40438
OWN - NLM
STAT- MEDLINE
DCOM- 19791229
LR  - 20171213
IS  - 0002-9513 (Print)
IS  - 0002-9513 (Linking)
VI  - 237
IP  - 5
DP  - 1979 Nov
TI  - Permanent changes of ventricular contractility and compliance in chronic volume 
      overload.
PG  - H575-83
AB  - Left ventricular volume overload (LVVO) has been created in 18 dogs by 
      anastomosing a Dacron conduit between the infrarenal abdominal aorta and inferior 
      vena cava. The dogs previously were instrumented so that in the awake state LV 
      pressure, systemic arterial pressure, LV dP/dt, myocardial segment length and 
      excursion, and coronary and renal artery velocities could be monitored. The 
      animals were stressed with separate infusions of alpha-adrenergic and 
      beta-adrenergic agonists. Both at rest and with stress, over a 12-wk period, 
      preejection, ejection, and contractility indices decreased. Left ventricular 
      compliance decreased as exemplified by the increased ratio of end-diastolic 
      pressure to end-diastolic length. The shunt was ablated in 7 dogs, and monitoring 
      in conjuction with alpha- and beta-adrenergic stress foan additional 12 wk 
      demonstrated an initial improvement in the previous indices. However, the 
      amelioration plateaued and values similar to the control state were not attained. 
      This suggests that potentially permanent alterations in ventricular function and 
      compliance have occurred.
FAU - Pinsky, W W
AU  - Pinsky WW
FAU - Lewis, R M
AU  - Lewis RM
FAU - Hartley, C J
AU  - Hartley CJ
FAU - Entman, M L
AU  - Entman ML
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Am J Physiol
JT  - The American journal of physiology
JID - 0370511
RN  - 0 (Adrenergic alpha-Agonists)
RN  - 0 (Adrenergic beta-Agonists)
SB  - IM
MH  - Adrenergic alpha-Agonists/pharmacology
MH  - Adrenergic beta-Agonists/pharmacology
MH  - Animals
MH  - Blood Pressure/drug effects
MH  - Compliance
MH  - Coronary Circulation
MH  - Diastole
MH  - Dogs
MH  - Heart Diseases/*physiopathology
MH  - Heart Rate/drug effects
MH  - Heart Ventricles/*physiopathology
MH  - *Myocardial Contraction/drug effects
EDAT- 1979/11/01 00:00
MHDA- 1979/11/01 00:01
CRDT- 1979/11/01 00:00
PHST- 1979/11/01 00:00 [pubmed]
PHST- 1979/11/01 00:01 [medline]
PHST- 1979/11/01 00:00 [entrez]
AID - 10.1152/ajpheart.1979.237.5.H575 [doi]
PST - ppublish
SO  - Am J Physiol. 1979 Nov;237(5):H575-83. doi: 10.1152/ajpheart.1979.237.5.H575.