PMID- 4044737
OWN - NLM
STAT- MEDLINE
DCOM- 19851113
LR  - 20190629
VI  - 331
IP  - 1
DP  - 1985 Aug 30
TI  - Determination of 2-(4-isobutylphenyl)propionic acid in bulk drug and compressed 
      tablets by reversed-phase high-performance liquid chromatography.
PG  - 169-76
AB  - A reversed-phase liquid chromatographic method was developed for 
      2-(4-isobutylphenyl)propionic acid (IBPP) in bulk drug and compressed tablets 
      containing 100-600 mg of drug per tablet. The chromatographic system consists of 
      a microparticulate octadecylsilica column and a mobile phase of aqueous 
      acetonitrile buffered with chloroacetic acid. Whole tablets are disintegrated, 
      and the IBPP dissolved in a solution of the internal standard in mobile phase. 
      The resulting suspension is then centrifuged, and an aliquot of the supernatant 
      chromatographed. This system separates IBPP from its analogues and degradation 
      products in less than 10 min. Recovery of the drug from spiked placebo 
      preparations was quantitative. Precision of the assay was 0.3 and 0.7%, relative 
      standard deviation, for bulk drug and Motrin tablets, respectively.
FAU - Asmus, P A
AU  - Asmus PA
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - J Chromatogr
JT  - Journal of chromatography
JID - 0427043
RN  - 0 (Tablets)
RN  - WK2XYI10QM (Ibuprofen)
SB  - IM
MH  - Chemical Phenomena
MH  - Chemistry
MH  - Chromatography, High Pressure Liquid
MH  - Ibuprofen/*analysis
MH  - Tablets
EDAT- 1985/08/30 00:00
MHDA- 1985/08/30 00:01
CRDT- 1985/08/30 00:00
PHST- 1985/08/30 00:00 [pubmed]
PHST- 1985/08/30 00:01 [medline]
PHST- 1985/08/30 00:00 [entrez]
AID - 10.1016/0021-9673(85)80018-2 [doi]
PST - ppublish
SO  - J Chromatogr. 1985 Aug 30;331(1):169-76. doi: 10.1016/0021-9673(85)80018-2.