PMID- 4047517
OWN - NLM
STAT- MEDLINE
DCOM- 19851112
LR  - 20131121
IS  - 0161-813X (Print)
IS  - 0161-813X (Linking)
VI  - 6
IP  - 3
DP  - 1985 Fall
TI  - Comparative toxicity of intracerebroventricular and subcutaneous aluminum in the 
      rabbit.
PG  - 71-80
AB  - Similar patterns of neurotoxicity were produced in rabbits receiving 20 to 28 
      subcutaneous (sc) 400 mumol/kg injections of aluminum (Al) lactate given during 1 
      month and in rabbits receiving a single 2.5 to 5 mumol Al injection into each 
      cerebral ventricle (icv). Predominant overt features of the Al-induced 
      encephalopathy included splayed limbs, seizures and postural changes. Elevated 
      brain Al concentrations, especially in cortical regions, were associated with 
      behavioral changes and the development of neurofibrillary tangles (NFTs). In 
      rabbits developing NFTs, an Al concentration of 3.5 micrograms/gm dry weight was 
      the minimal concentration associated with tangle formation. However, no 
      correlation was seen between brain Al concentration and the number of NFTs 
      produced. Elevated brain Al concentrations and symptoms of Al-induced 
      encephalopathy were seen approximately 12 days after icv and 18 days after 
      completion of sc Al injections. The results from the present study demonstrate 
      that the neuropathology, brain aluminum concentrations, and behavioral 
      symptomatology produced by centrally administered Al can be replicated by 
      administration of an adequate dose of peripherally administered Al. Furthermore, 
      an advantage of peripheral Al administration over icv Al administration is that a 
      longer period of time is seen between dosing and the full onset of the 
      encephalopathy, providing more time to study the effects of Al intoxication.
FAU - Forrester, T M
AU  - Forrester TM
FAU - Yokel, R A
AU  - Yokel RA
LA  - eng
GR  - ES 2676/ES/NIEHS NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - Neurotoxicology
JT  - Neurotoxicology
JID - 7905589
RN  - CPD4NFA903 (Aluminum)
SB  - IM
MH  - Aluminum/administration & dosage/metabolism/*toxicity
MH  - Animals
MH  - Brain/*drug effects
MH  - Eating/drug effects
MH  - Injections, Intraventricular
MH  - Injections, Subcutaneous
MH  - Neurons/drug effects
MH  - Postural Balance/drug effects
MH  - Rabbits
MH  - Time Factors
MH  - Tissue Distribution
EDAT- 1985/01/01 00:00
MHDA- 1985/01/01 00:01
CRDT- 1985/01/01 00:00
PHST- 1985/01/01 00:00 [pubmed]
PHST- 1985/01/01 00:01 [medline]
PHST- 1985/01/01 00:00 [entrez]
PST - ppublish
SO  - Neurotoxicology. 1985 Fall;6(3):71-80.