PMID- 4048239
OWN - NLM
STAT- MEDLINE
DCOM- 19851118
LR  - 20190712
IS  - 0091-3057 (Print)
IS  - 0091-3057 (Linking)
VI  - 23
IP  - 3
DP  - 1985 Sep
TI  - Prenatal nicotine affects fetal testosterone and sexual dimorphism of saccharin 
      preference.
PG  - 439-44
AB  - In order to study effects of nicotine on fetal gonadal axis and sexually 
      dimorphic behavior, time-pregnant Sprague Dawley rats were implanted on 
      gestational day (GD) 12 with an osmotic minipump containing either nicotine 
      tartrate, tartaric acid or saline. Others were sham-operated on GD 12 or left 
      untreated. Male fetuses of all control groups displayed the characteristic rise 
      in plasma testosterone at GD 18 (as compared to GD 17 and 19); this was abolished 
      by nicotine. Adult offspring of untreated or tartaric acid-treated dams exhibited 
      a marked sexual dimorphism in their preference for saccharin-containing drinking 
      water at 0.06-0.25%. No such sex difference was seen in offspring of 
      nicotine-treated rats. In controls, the sexes differed with respect to the 
      proportion of rats with high saccharin preference. In the group of males 
      prenatally exposed to nicotine, the proportion of animals with high preference 
      increased to the female level. These data indicate that prenatal exposure to 
      nicotine can interfere with the development of the male gonadal axis and with the 
      organization of sexually dimorphic behavior.
FAU - Lichtensteiger, W
AU  - Lichtensteiger W
FAU - Schlumpf, M
AU  - Schlumpf M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Pharmacol Biochem Behav
JT  - Pharmacology, biochemistry, and behavior
JID - 0367050
RN  - 3XMK78S47O (Testosterone)
RN  - 6M3C89ZY6R (Nicotine)
RN  - FST467XS7D (Saccharin)
SB  - IM
MH  - Animals
MH  - Choice Behavior/drug effects
MH  - Female
MH  - Fetus/metabolism
MH  - Nicotine/*toxicity
MH  - Pregnancy
MH  - Prenatal Exposure Delayed Effects
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Saccharin/pharmacology
MH  - *Sex Characteristics
MH  - Testosterone/*blood
EDAT- 1985/09/01 00:00
MHDA- 1985/09/01 00:01
CRDT- 1985/09/01 00:00
PHST- 1985/09/01 00:00 [pubmed]
PHST- 1985/09/01 00:01 [medline]
PHST- 1985/09/01 00:00 [entrez]
AID - 0091-3057(85)90018-8 [pii]
AID - 10.1016/0091-3057(85)90018-8 [doi]
PST - ppublish
SO  - Pharmacol Biochem Behav. 1985 Sep;23(3):439-44. doi: 
      10.1016/0091-3057(85)90018-8.