PMID- 4054822
OWN - NLM
STAT- MEDLINE
DCOM- 19851210
LR  - 20131121
IS  - 0367-6102 (Print)
IS  - 0367-6102 (Linking)
VI  - 60
IP  - 4
DP  - 1985 Jul
TI  - [Effects of new antihypertensive agent, 
      2-[4-(n-butyryl)-homopiperazine-1-ul]-4-amino-6, 7-dimethoxy-quinazoline (E-643), 
      on blood pressure, urinary sodium excretion and urinary norepinephrine excretion 
      rate in stroke-prone, spontaneously hypertensive rats].
PG  - 536-43
AB  - Present study was undertaken to elucidate the effects of E-643, on blood 
      pressure, urinary electrolyte (U-Na, U-K) and catecholamines excretion rates in 
      stroke-prone spontaneously hypertensive rats (SHRSP). An attempt was also made to 
      clarify the effects of E-643 on plasma catecholamine concentration and 
      sympathetic efferent nerve discharges including renal and adrenal nerve activity. 
      E-643 (10 mg/kg/day X 4 weeks, p.o.) administered SHRSP (E-643 SHRSP) produced a 
      significant hypotensive effect as compared with sex-age matched nondrug control 
      SHRSP (control SHRSP). Both U-Na and U-K in E-643 SHRSP increased significantly 
      as compared with those of control SHRSP. Urinary norepinephrine content (U-NE) 
      also increased significantly in E-643 SHRSP. Plasma NE concentration tended to 
      increase in E-643 SHRSP. While, plasma epinephrine (E) concentration decreased 
      significantly in E-643 SHRSP. E-643 did not produce any significant effects on 
      both sympathetic renal nerve activity and adrenal nerve activity in SHR. The 
      changes induced by exogenous administered NE (blood pressure rise, tachycardia 
      and the change in sympathetic nerve activity) were antagonized by pretreatment of 
      E-643 in SHR. It was demonstrated that therapeutic doses of E-643 did not seem to 
      produce any significant effect on central nervous system. These findings suggest 
      that E-643 is a peripherally acting alpha 1 antagonist with natriuretic effect.
FAU - Minami, M
AU  - Minami M
FAU - Togashi, H
AU  - Togashi H
FAU - Sano, M
AU  - Sano M
FAU - Yoshioka, M
AU  - Yoshioka M
FAU - Saito, I
AU  - Saito I
FAU - Morii, K
AU  - Morii K
FAU - Tochihara, M
AU  - Tochihara M
FAU - Hirogami, M
AU  - Hirogami M
FAU - Nomura, A
AU  - Nomura A
FAU - Saito, H
AU  - Saito H
LA  - jpn
PT  - English Abstract
PT  - Journal Article
PL  - Japan
TA  - Hokkaido Igaku Zasshi
JT  - [Hokkaido igaku zasshi] The Hokkaido journal of medical science
JID - 17410290R
RN  - 0 (Antihypertensive Agents)
RN  - 0 (Catecholamines)
RN  - 0 (Quinazolines)
RN  - 9UUW4V7G2H (bunazosin)
RN  - RWP5GA015D (Potassium)
RN  - X4W3ENH1CV (Norepinephrine)
SB  - IM
MH  - Animals
MH  - Antihypertensive Agents/*pharmacology
MH  - Blood Pressure/*drug effects
MH  - Body Weight/drug effects
MH  - Catecholamines/blood
MH  - Cerebrovascular Disorders/etiology
MH  - Eating/drug effects
MH  - Heart Rate/drug effects
MH  - Humans
MH  - Hypertension/metabolism/*physiopathology
MH  - Kidney/innervation
MH  - Male
MH  - Natriuresis/*drug effects
MH  - Norepinephrine/*urine
MH  - Potassium/urine
MH  - Quinazolines/*pharmacology
MH  - Rats
MH  - Rats, Inbred SHR
EDAT- 1985/07/01 00:00
MHDA- 1985/07/01 00:01
CRDT- 1985/07/01 00:00
PHST- 1985/07/01 00:00 [pubmed]
PHST- 1985/07/01 00:01 [medline]
PHST- 1985/07/01 00:00 [entrez]
PST - ppublish
SO  - Hokkaido Igaku Zasshi. 1985 Jul;60(4):536-43.