PMID- 4055989
OWN - NLM
STAT- MEDLINE
DCOM- 19851219
LR  - 20211203
IS  - 0271-9142 (Print)
IS  - 0271-9142 (Linking)
VI  - 5
IP  - 5
DP  - 1985 Sep
TI  - Urinary IgA in IgA nephropathy and Henoch-Schoenlein purpura.
PG  - 298-306
AB  - To determine the concentrations and molecular forms of urinary IgA in IgA 
      nephropathy and Henoch-Schoenlein purpura, we studied 29 patients with these 
      IgA-associated renal diseases (IgAN). Control groups comprised 10 patients with 
      other diverse renal disease and 11 healthy volunteers. Urinary IgA and IgG 
      concentrations were higher in IgAN than in either control group and correlated 
      positively with the serum creatinine concentration as well as the urinary protein 
      excretion (P less than 0.01). However, IgA/IgG ratios did not differ among the 
      three groups. Polymeric IgA (p-IgA) in the urine predominated only in normals; in 
      IgAN and patients with other renal diseases, monomeric IgA (m-IgA) occurred 
      almost exclusively. Serum IgA concentrations were generally normal in IgAN; four 
      patients had concentrations greater than 500 mg/dl. Although the fraction of 
      p-IgA in serum (median, 18%) was increased above normal (5-10%) in 13 of 16 (81%) 
      subjects, neither the concentration of IgA or IgG nor the amount of p-IgA 
      correlated with the serum creatinine concentration. These data suggest that the 
      molecular form and concentration of urinary IgA are not discriminating for IgAN 
      and are independent of these characteristics of serum IgA.
FAU - Galla, J H
AU  - Galla JH
FAU - Spotswood, M F
AU  - Spotswood MF
FAU - Harrison, L A
AU  - Harrison LA
FAU - Mestecky, J
AU  - Mestecky J
LA  - eng
GR  - AI 18745/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - J Clin Immunol
JT  - Journal of clinical immunology
JID - 8102137
RN  - 0 (Immunoglobulin A)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Immunoglobulins)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Child
MH  - Child, Preschool
MH  - Chromatography, Gel
MH  - Female
MH  - Glomerulonephritis, IGA/*immunology
MH  - Humans
MH  - IgA Vasculitis/*immunology
MH  - Immunoglobulin A/isolation & purification/*urine
MH  - Immunoglobulin G/isolation & purification/urine
MH  - Immunoglobulins/analysis
MH  - Male
MH  - Middle Aged
MH  - Radioimmunoassay
MH  - Reference Values
EDAT- 1985/09/01 00:00
MHDA- 1985/09/01 00:01
CRDT- 1985/09/01 00:00
PHST- 1985/09/01 00:00 [pubmed]
PHST- 1985/09/01 00:01 [medline]
PHST- 1985/09/01 00:00 [entrez]
AID - 10.1007/BF00918248 [doi]
PST - ppublish
SO  - J Clin Immunol. 1985 Sep;5(5):298-306. doi: 10.1007/BF00918248.