PMID- 4059160
OWN - NLM
STAT- MEDLINE
DCOM- 19851220
LR  - 20161123
IS  - 0032-5473 (Print)
IS  - 0032-5473 (Linking)
VI  - 61 Suppl 1
DP  - 1985
TI  - Toxic shock syndrome in Britain--epidemiology and microbiology.
PG  - 5-21
AB  - By 30 June 1984, only 99 confirmed and probable cases of toxic shock syndrome 
      (TSS) had been reported in the British Isles. Sixty-three were related to 
      menstruation in women aged 14 to 54 years who used tampons of various brands and 
      absorbencies; 33 (52%) of these cases were in girls under 20. Five women died 
      (8%) and 19 (30%) reported at least one other possible episode. Thirty-six cases 
      associated with a variety of clinical conditions occurred in men aged 17 to 74 
      years (9), women aged 20 to 54 years (15) and 12 children aged 10 months to 10 
      years; six patients (17%) died. Strains of Staphylococcus aureus which produced 
      toxic shock syndrome toxin 1 (TSST-1) were isolated from 53 of 58 (91%) 
      menstrual, but only from 18 of 33 (54%) non-menstrual patients. The frequency of 
      toxin production was highest (93%) for 56 vaginal isolates and lowest (33%) for 9 
      isolates from blood culture. Ninety-six percent (68 of 71) of strains that were 
      TSST-1-positive were sensitive to lytic-group I phages at one of the three 
      concentrations tested; 82% were lysed by phage 29. Nineteen percent of 339 
      strains from a variety of sources other than TSS, produced TSST-1, and 35% of the 
      strains lysed by group I phages were positive. Antibody to TSST-1 was detected by 
      enzyme-linked immunosorbent assay at a serum dilution of 1:100, in 232 of 320 
      (82%) healthy individuals aged 14 to 56 years, but in acute-phase sera from only 
      four of 37 (18%) TSS patients. A rise in antibody levels during convalescence was 
      noted in two menstrual and 5 non-menstrual patients. These results show that the 
      epidemiology of TSS is similar in Britain and the United States and provide 
      further evidence of the importance of TSST-1-producing strains in the aetiology 
      of the disease.
FAU - de Saxe, M J
AU  - de Saxe MJ
FAU - Hawtin, P
AU  - Hawtin P
FAU - Wieneke, A A
AU  - Wieneke AA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Postgrad Med J
JT  - Postgraduate medical journal
JID - 0234135
RN  - 0 (Antibodies)
RN  - 0 (Bacterial Toxins)
RN  - 0 (Enterotoxins)
RN  - 0 (Superantigens)
RN  - 0 (enterotoxin F, Staphylococcal)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Antibodies/analysis
MH  - *Bacterial Toxins
MH  - Child
MH  - Child, Preschool
MH  - Enterotoxins/biosynthesis/immunology
MH  - Female
MH  - Humans
MH  - Infant
MH  - Male
MH  - Menstrual Hygiene Products/adverse effects
MH  - Menstruation
MH  - Middle Aged
MH  - Postoperative Complications
MH  - Shock, Septic/*epidemiology/etiology/microbiology
MH  - Staphylococcus aureus/isolation & purification/metabolism
MH  - *Superantigens
MH  - Surgical Wound Infection/complications
MH  - United Kingdom
EDAT- 1985/01/01 00:00
MHDA- 1985/01/01 00:01
CRDT- 1985/01/01 00:00
PHST- 1985/01/01 00:00 [pubmed]
PHST- 1985/01/01 00:01 [medline]
PHST- 1985/01/01 00:00 [entrez]
PST - ppublish
SO  - Postgrad Med J. 1985;61 Suppl 1:5-21.