PMID- 4064578
OWN - NLM
STAT- MEDLINE
DCOM- 19851226
LR  - 20190820
IS  - 0143-5221 (Print)
IS  - 0143-5221 (Linking)
VI  - 69
IP  - 6
DP  - 1985 Dec
TI  - The effect of hypoglycaemia on visual function: a clinical and 
      electrophysiological study.
PG  - 673-9
AB  - Disturbance of vision commonly accompanies hypoglycaemia. This study was designed 
      to investigate the nature of the visual disturbance, the blood glucose threshold 
      at which the disturbance occurred and the physiological basis. Measurements were 
      made of the corrected visual acuity, colour vision (100 Hue test), visual evoked 
      potentials (VEP), electroencephalography (EEG) frequency analysis and psychometry 
      (digit recall) during stepwise induction of controlled hypoglycaemia produced by 
      an intravenous insulin infusion. Six male volunteers and five insulin-dependent 
      diabetic subjects were studied. During hypoglycaemia corrected visual acuity was 
      unchanged. Colour vision was significantly impaired. Baseline VEP were normal in 
      both groups but significantly prolonged during hypoglycaemia (mean increment 10.8 
      ms) and increased by greater than 5 ms in nine out of 11 subjects. Quantitative 
      EEG analysis demonstrated slowing with a power density spectral shift from fast 
      alpha to slow alpha, theta and delta which correlated with VEP latency and 
      amplitude changes. The findings have clinical implications. A deterioration in 
      colour vision is likely to impair the ability to read reagent strips by eye. VEP 
      measurements in diabetic patients are likely to be misleading if hypoglycaemia is 
      present; EEG changes are a sensitive index of cortical dysfunction during 
      hypoglycaemia and provide a theoretical basis for developing a portable device to 
      detect early hypoglycaemia.
FAU - Harrad, R A
AU  - Harrad RA
FAU - Cockram, C S
AU  - Cockram CS
FAU - Plumb, A P
AU  - Plumb AP
FAU - Stone, S
AU  - Stone S
FAU - Fenwick, P
AU  - Fenwick P
FAU - Sonksen, P H
AU  - Sonksen PH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Clin Sci (Lond)
JT  - Clinical science (London, England : 1979)
JID - 7905731
RN  - 0 (Blood Glucose)
SB  - IM
MH  - Adult
MH  - Blood Glucose/metabolism
MH  - Color Perception
MH  - Diabetes Mellitus, Type 1/*physiopathology
MH  - Electroencephalography
MH  - Evoked Potentials, Visual
MH  - Humans
MH  - Hypoglycemia/*physiopathology
MH  - Male
MH  - Middle Aged
MH  - Psychometrics
MH  - *Vision, Ocular
MH  - Visual Acuity
EDAT- 1985/12/01 00:00
MHDA- 1985/12/01 00:01
CRDT- 1985/12/01 00:00
PHST- 1985/12/01 00:00 [pubmed]
PHST- 1985/12/01 00:01 [medline]
PHST- 1985/12/01 00:00 [entrez]
AID - 10.1042/cs0690673 [doi]
PST - ppublish
SO  - Clin Sci (Lond). 1985 Dec;69(6):673-9. doi: 10.1042/cs0690673.