PMID- 407125
OWN - NLM
STAT- MEDLINE
DCOM- 19770922
LR  - 20210915
IS  - 0016-6731 (Print)
IS  - 0016-6731 (Linking)
VI  - 86
IP  - 1
DP  - 1977 May
TI  - The genetic structure of natural populations of Drosophila melanogaster XIII. 
      Further studies on linkage disequilibrium.
PG  - 175-85
AB  - The Raleigh, North Carolina, population of Drosophila melanogaster was examined 
      for linkage disequilibrium in 1974, several years after previous analyses in 
      1968, 1969, and 1970. alphaglycerol-3-phosphate dehydrogenase-1 (alphaGpdh-1), 
      malate dehydrogenase-1 (Mdh-1), alcohol dehydrogenase (Adh), and hexokinase-C 
      (Hex-C, tentative name, F. M. Johnson, unpublished; position determined by the 
      present authors to be 2-74.5) were assayed for 617 second chromosomes, and 
      esterase-C (Est-C) and octanol dehydrogenase (Odh) were assayed for 526 third 
      chromosomes. In addition, two polymorphic inversions in the second chromosomes 
      [In(2L)t and In(2R)NS] were examined, and the following findings were obtained: 
      (1) No linkage disequilibrium between isozyme genes was detected. Significant 
      linkage disequilibria were found only between the polymorphic inversions and 
      isozyme genes [In(2L)t vs. Adh, and In(2R)NS vs. Hex-C]. Significant 
      disequilibrium was not detected between In(2L)t and alphaGpdh-1, which is 
      included in the inversion, but a tendency toward disequilibrium was consistently 
      found from 1968 to 1974. The frequency of two-strand double crossovers within 
      inversion In(2L)t involving a single crossover on each side of alphaGpdh-1 was 
      estimated to be 0.00022. Thus, the consistent but not significant linkage 
      disequilibrium between the two factors can be explained by recombination after 
      the inversion occurred. (2) Previously existing linkage disequilibrium between 
      Adh and In(2R)NS (the distance is about 30 cM, but the effective recombination 
      value is about 1.75%) was found to have disappeared. (3) No higher-order linkage 
      disequilibrium was detected. (4) Linkage disequilibrium between Odh and Est-C 
      (the distance of which was estimated to be 0.0058 +/- 0.002) could not be 
      detected (chi(2) (df=1) = 0.9).-From the above results, it was concluded that 
      linkage disequilibria among isozyme genes are very rare in D. melanogaster, so 
      that the Franklin-Lewontin model (Franklin and Lewontin 1970) is not applicable 
      to these genes. The linkage disequilibria between some isozyme genes and 
      polymorphic inversions may be explained by founder effect.
FAU - Mukai, T
AU  - Mukai T
FAU - Voelker, R A
AU  - Voelker RA
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Genetics
JT  - Genetics
JID - 0374636
RN  - 0 (Isoenzymes)
SB  - IM
MH  - Alleles
MH  - Animals
MH  - *Drosophila melanogaster
MH  - Female
MH  - Gene Frequency
MH  - *Genetic Linkage
MH  - *Genetics, Population
MH  - Hybrid Vigor
MH  - Isoenzymes/analysis
MH  - Male
MH  - Polymorphism, Genetic
MH  - Recombination, Genetic
PMC - PMC1213663
EDAT- 1977/05/01 00:00
MHDA- 1977/05/01 00:01
PMCR- 1977/08/01
CRDT- 1977/05/01 00:00
PHST- 1977/05/01 00:00 [pubmed]
PHST- 1977/05/01 00:01 [medline]
PHST- 1977/05/01 00:00 [entrez]
PHST- 1977/08/01 00:00 [pmc-release]
AID - 10.1093/genetics/86.1.175 [doi]
PST - ppublish
SO  - Genetics. 1977 May;86(1):175-85. doi: 10.1093/genetics/86.1.175.