PMID- 4071554
OWN - NLM
STAT- MEDLINE
DCOM- 19860110
LR  - 20190819
IS  - 0300-483X (Print)
IS  - 0300-483X (Linking)
VI  - 37
IP  - 3-4
DP  - 1985 Dec
TI  - Studies on the copper and zinc content of the rat kidney after treatment with 
      cisplatin.
PG  - 267-74
AB  - The administration of cis-dichlorodiammine platinum II (cisplatin), at a dose of 
      5 mg/kg, subcutaneously (s.c.), to adult male Wistar rats, inhibited the normal 
      accumulation of Cu and Zn in the kidneys. Cisplatin also produced a small 
      increase in the concentration of Cu in the brain but had no significant effect on 
      total Cu and Zn concentrations in the heart, thymus, liver, intestine, spleen, 
      testes and muscle. Treatment of rats with 2 mg Cu2+/kg, intraperitoneally (i.p.), 
      increased the renal Cu content whilst cisplatin pretreatment inhibited the uptake 
      of Cu by the kidneys. The administration of cisplatin to the Cd2+-pretreated rat 
      decreased the content of metallothionein-bound Cu in parallel with a reduction in 
      total renal Cu content, but had no significant effect on the total renal content 
      of Cd and Zn. Pretreatment with cisplatin decreased the subsequent uptake of Cd 
      by 42% in the whole kidney and by 23% in the metallothionein fraction, but failed 
      to reduce the Cd2+-induced accumulation of Cu in the kidneys. The significance of 
      these observations in relation to the possible mechanism of the cisplatin-induced 
      change in the Cu and Zn content of the kidney is discussed.
FAU - Mason, R W
AU  - Mason RW
FAU - Edwards, I R
AU  - Edwards IR
LA  - eng
PT  - Journal Article
PL  - Ireland
TA  - Toxicology
JT  - Toxicology
JID - 0361055
RN  - 00BH33GNGH (Cadmium)
RN  - 789U1901C5 (Copper)
RN  - J41CSQ7QDS (Zinc)
RN  - Q20Q21Q62J (Cisplatin)
SB  - IM
MH  - Animals
MH  - Cadmium/metabolism
MH  - Cisplatin/*pharmacology
MH  - Copper/*metabolism
MH  - Drug Interactions
MH  - Injections, Intraperitoneal
MH  - Injections, Subcutaneous
MH  - Kidney/*drug effects/metabolism
MH  - Male
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Spectrophotometry, Atomic
MH  - Tissue Distribution
MH  - Zinc/*metabolism
EDAT- 1985/12/01 00:00
MHDA- 1985/12/01 00:01
CRDT- 1985/12/01 00:00
PHST- 1985/12/01 00:00 [pubmed]
PHST- 1985/12/01 00:01 [medline]
PHST- 1985/12/01 00:00 [entrez]
AID - 0300-483X(85)90090-3 [pii]
AID - 10.1016/0300-483x(85)90090-3 [doi]
PST - ppublish
SO  - Toxicology. 1985 Dec;37(3-4):267-74. doi: 10.1016/0300-483x(85)90090-3.