PMID- 4072731
OWN - NLM
STAT- MEDLINE
DCOM- 19860103
LR  - 20190815
IS  - 0001-690X (Print)
IS  - 0001-690X (Linking)
VI  - 72
IP  - 3
DP  - 1985 Sep
TI  - Prolactin and thyrotropin in serum during electroconvulsive therapy in patients 
      with major depressive illness.
PG  - 302-8
AB  - Thirty-three patients with major depressive illness received electroconvulsive 
      therapy (ECT), and serum prolactin (PRL) and thyrotropin (TSH) levels were 
      measured 30 min before and 1, 5, 15, 30, and 60 min after the treatment. There 
      was a threefold increase in PRL levels with a maximum after 15 min. The TSH 
      plasma levels rose significantly with a maximum at 30 min after ECT. No change in 
      PRL and TSH concentrations was seen in control experiments when the patients 
      received anaesthesia only. In 15 patients the hormone levels were studied both 
      during the first and sixth (last) ECT. The PRL and TSH levels were significantly 
      higher following the first as compared to the sixth ECT. Patients on 
      phenothiazines had higher PRL and lower TSH levels than those on other drugs or 
      without medication, but there was no significant difference in the mean increment 
      by ECT. Dopamine depresses PRL and TSH secretion. The diminished hormone release 
      after a series of ECT may be explained by ECT-induced increase of postsynaptic 
      dopamine receptor function leading to inhibition of PRL and TSH release from the 
      pituitary gland.
FAU - Aperia, B
AU  - Aperia B
FAU - Thoren, M
AU  - Thoren M
FAU - Wetterberg, L
AU  - Wetterberg L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Acta Psychiatr Scand
JT  - Acta psychiatrica Scandinavica
JID - 0370364
RN  - 9002-62-4 (Prolactin)
RN  - 9002-71-5 (Thyrotropin)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Anesthesia
MH  - Circadian Rhythm
MH  - Depressive Disorder/*blood/therapy
MH  - *Electroconvulsive Therapy/methods
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prolactin/*blood
MH  - Thyrotropin/*blood
MH  - Time Factors
EDAT- 1985/09/01 00:00
MHDA- 1985/09/01 00:01
CRDT- 1985/09/01 00:00
PHST- 1985/09/01 00:00 [pubmed]
PHST- 1985/09/01 00:01 [medline]
PHST- 1985/09/01 00:00 [entrez]
AID - 10.1111/j.1600-0447.1985.tb02611.x [doi]
PST - ppublish
SO  - Acta Psychiatr Scand. 1985 Sep;72(3):302-8. doi: 
      10.1111/j.1600-0447.1985.tb02611.x.