PMID- 4075606
OWN - NLM
STAT- MEDLINE
DCOM- 19860131
LR  - 20190511
IS  - 0160-9289 (Print)
IS  - 0160-9289 (Linking)
VI  - 8
IP  - 12
DP  - 1985 Dec
TI  - Intravenous versus intracoronary streptokinase in acute myocardial infarction.
PG  - 609-19
AB  - Nine studies specifically dealing with the comparison of intravenous 
      streptokinase (IVSK) and intracoronary streptokinase (ICSK) in the treatment of 
      acute myocardial infarction (MI) were analyzed to determine if IVSK is as 
      efficacious as ICSK in achieving thrombolysis. Pooled data from the studies 
      yielded success rates of 73% for IVSK and 72% for ICSK. Considering that the 
      studies which did not perform preintervention angiogram may have overestimated 
      the thrombolytic success rate in IVSK patients, there is a possibility that ICSK 
      may be slightly more effective in achieving acute reperfusion. Bleeding 
      complications were similar, and a systemic lytic state was observed in both 
      treatment groups. No definitive conclusions can be drawn regarding the 
      differences between groups in improvements of left ventricular function and 
      mortality rates. ICSK has the advantage of direct documentation of reperfusion 
      and spares the patient the risk of anticoagulation should the attempt fail. On 
      the other hand, IVSK is cheaper, easier to administer, and can logistically be 
      given earlier (even in the emergency room or ambulance) than ICSK; it is 
      therefore more widely available, and may be the preferred mode of treatment in 
      community hospitals where cardiac catheterization facilities are not readily 
      available, if streptokinase is to be given at all.
FAU - Lo, Y S
AU  - Lo YS
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - Clin Cardiol
JT  - Clinical cardiology
JID - 7903272
RN  - EC 3.4.- (Streptokinase)
SB  - IM
MH  - Cardiac Output/drug effects
MH  - Coronary Circulation/drug effects
MH  - Coronary Vessels/*drug effects
MH  - Dose-Response Relationship, Drug
MH  - Humans
MH  - Infusions, Parenteral
MH  - Myocardial Contraction/drug effects
MH  - Myocardial Infarction/*drug therapy/mortality
MH  - Prognosis
MH  - Recurrence
MH  - Streptokinase/*administration & dosage/adverse effects
EDAT- 1985/12/01 00:00
MHDA- 1985/12/01 00:01
CRDT- 1985/12/01 00:00
PHST- 1985/12/01 00:00 [pubmed]
PHST- 1985/12/01 00:01 [medline]
PHST- 1985/12/01 00:00 [entrez]
AID - 10.1002/clc.4960081202 [doi]
PST - ppublish
SO  - Clin Cardiol. 1985 Dec;8(12):609-19. doi: 10.1002/clc.4960081202.