PMID- 4091489
OWN - NLM
STAT- MEDLINE
DCOM- 19860326
LR  - 20061115
IS  - 0003-4193 (Print)
IS  - 0003-4193 (Linking)
VI  - 16
IP  - 4
DP  - 1985
TI  - Vaccination of ewes by a single conjunctival administration of Brucella 
      melitensis Rev. 1 vaccine.
PG  - 351-6
AB  - In a lot of 99 ewes, the efficacy of a single vaccination by the conjunctival 
      route (VC) with either 1.4 X 10(8) or 1.4 X 10(9) CFU Brucella melitensis Rev. 1 
      was compared with that of normal subcutaneous (SC) vaccination with 1.6 X 10(9) 
      CFU. The ewes were challenged seven months after vaccination, when 85 days 
      pregnant, with 5 X 10(7) CFU Brucella melitensis strain H38 administered by 
      conjunctival route. Complement fixation, Rose Bengal and allergic tests were 
      performed at intervals between vaccination and slaughter, and clinical and 
      bacteriological examinations between challenge and slaughter, six weeks after 
      lambing. After VC vaccination, few animals showed Brucella antibodies whatever 
      the dose, and all were seronegative as early as four months after vaccination 
      whereas a few SC vaccinated individuals were still seropositive at ten months. 
      There were more allergic reactions among SC than VC animals, but sensitization 
      was shown to be long-lasting in all vaccinated groups, whatever the 
      administration route of the vaccine. VC vaccination with 10(9) CFU appeared to 
      afford slightly greater protection than that with 10(8) CFU, and slightly lower 
      protection than that induced by SC vaccination, but differences were not 
      statistically significant. It is suggested that conjunctival vaccination with 
      10(9) CFU Rev. 1 would induce a good level of protection against Brucella 
      melitensis infection and allow test and slaughter procedures as early as four 
      months after vaccination.
FAU - Fensterbank, R
AU  - Fensterbank R
FAU - Pardon, P
AU  - Pardon P
FAU - Marly, J
AU  - Marly J
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - France
TA  - Ann Rech Vet
JT  - Annales de recherches veterinaires. Annals of veterinary research
JID - 1267230
RN  - 0 (Brucella Vaccine)
SB  - IM
MH  - Animals
MH  - Brucella Vaccine/*administration & dosage
MH  - Brucellosis/prevention & control/*veterinary
MH  - Conjunctiva
MH  - Female
MH  - Injections, Subcutaneous
MH  - Sheep
MH  - Sheep Diseases/*prevention & control
EDAT- 1985/01/01 00:00
MHDA- 1985/01/01 00:01
CRDT- 1985/01/01 00:00
PHST- 1985/01/01 00:00 [pubmed]
PHST- 1985/01/01 00:01 [medline]
PHST- 1985/01/01 00:00 [entrez]
PST - ppublish
SO  - Ann Rech Vet. 1985;16(4):351-6.