PMID- 4093622
OWN - NLM
STAT- MEDLINE
DCOM- 19860410
LR  - 20131121
IS  - 0386-2887 (Print)
IS  - 0386-2887 (Linking)
VI  - 15
IP  - 2
DP  - 1985 Jun
TI  - [Regional left ventricular function in dilated cardiomyopathy: observation of 
      regional left ventricular wall motion before and during dobutamine 
      administration].
PG  - 387-98
AB  - To investigate left ventricular function and the prognosis of patients with 
      dilated cardiomyopathy (DCM), regional wall motion of the left ventricle of 38 
      patients with DCM was observed before and during dobutamine infusion (8 
      micrograms/kg X min) by two-dimensional echocardiography (2DE). The left 
      ventricle was divided into 11 segments and the severity of wall motion 
      abnormality (WMA) was classified into 4 grades, i.e. akinesis or dyskinesis (A), 
      severe hypokinesis (SH), hypokinesis (H) and normokinesis (N), and numerical 
      scores were assigned to each grade of WMA as follow; A: 3, SH: 2, H: 1, and N: 0. 
      In the 38 patients with DCM, the number of segments with WMA was 8.3 +/- 2.9 
      (mean +/- SD). Among 418 segments in the 38 patients, we observed A in 71 
      segments, SH in 104 segments, H in 140 segments, and N in 103 segments. The WMA 
      was not uniform in the left ventricle, and severe WMA was observed in the apex 
      (WMA score: 2.0 +/- 1.0), while the grades of WMA in the lateral and posterior 
      walls were mild (WMA score: 0.8 +/- 1.1) compared with those of other segments. 
      The total sums of the WMA scores in 11 segments for each patient (TWMAS) were 
      significantly greater in patients with severe heart failure (New York Heart 
      Association [NYHA] functional class III or IV) than in patients with mild heart 
      failure (NYHA class I or II) (22.0 +/- 5.2 and 9.9 +/- 4.9, p less than 0.001). 
      TWMAS correlated with the cardiac index (CI) (r = -0.58, p less than 0.005) and 
      pulmonary capillary pressure (PCP) (r = 0.68, p less than 0.001). In 242 segments 
      of 22 patients, whose regional wall motion was observed before and during 
      dobutamine administration, wall motion was improved by one grade in 82 of 170 
      segments with WMA before dobutamine infusion; i.e. regional wall motion changed 
      from A to SH in six segments, from SH to H in 31 segments, and from H to N in 45 
      segments with dobutamine administration. According to the change in grade of 
      TWMAS induced by dobutamine administration, 22 patients with DCM were classified 
      into two groups: a good response group (% change of TWMAS greater than or equal 
      to 40%), and a poor response group (% change of TWMAS less than 40%). The poor 
      response group had ventricular tachycardia more frequently, more severe heart 
      failure, lower CI and higher PCP than the good response group.(ABSTRACT TRUNCATED 
      AT 400 WORDS)
FAU - Kubo, M
AU  - Kubo M
FAU - Yokota, Y
AU  - Yokota Y
FAU - Takarada, A
AU  - Takarada A
FAU - Kumaki, T
AU  - Kumaki T
FAU - Seo, T
AU  - Seo T
FAU - Maehashi, N
AU  - Maehashi N
FAU - Toh, S
AU  - Toh S
FAU - Hayakawa, M
AU  - Hayakawa M
FAU - Inoh, T
AU  - Inoh T
FAU - Fukuzaki, H
AU  - Fukuzaki H
LA  - jpn
PT  - English Abstract
PT  - Journal Article
PL  - Japan
TA  - J Cardiogr
JT  - Journal of cardiography
JID - 7801085
RN  - 3S12J47372 (Dobutamine)
SB  - IM
MH  - Adult
MH  - Cardiomyopathy, Dilated/drug therapy/*physiopathology
MH  - Dobutamine/*therapeutic use
MH  - *Echocardiography
MH  - Female
MH  - Heart Failure/physiopathology
MH  - Heart Ventricles/drug effects/*physiopathology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Mitral Valve/physiopathology
MH  - Myocardial Contraction/*drug effects
MH  - Papillary Muscles/physiopathology
MH  - Prognosis
EDAT- 1985/06/01 00:00
MHDA- 1985/06/01 00:01
CRDT- 1985/06/01 00:00
PHST- 1985/06/01 00:00 [pubmed]
PHST- 1985/06/01 00:01 [medline]
PHST- 1985/06/01 00:00 [entrez]
PST - ppublish
SO  - J Cardiogr. 1985 Jun;15(2):387-98.