PMID- 4140271
OWN - NLM
STAT- MEDLINE
DCOM- 19750310
LR  - 20190611
IS  - 0140-6736 (Print)
IS  - 0140-6736 (Linking)
VI  - 2
IP  - 7880
DP  - 1974 Sep 7
TI  - Radioimmunoassay of cannabinoids in blood and urine.
PG  - 553-5
AB  - A radioimmunoassay (R.I.A.), using a sheep antiserum and 3-H-T.H.C., has been 
      developed for the measurement of tetrahydrocannabinol (T.H.C.) in plasma and 
      urine. The antiserum cross-reacts with T.H.C. metabolites, but nevertheless 
      possesses sufficient group specificity and sensitivity to permit measurement of 
      cannabinoids in plasma and urine of animals and volunteers following the 
      administration of pure T.H.C. Subjective effects experienced by the volunteers 
      seemed to correlate with plasma-T.H.C. levels. The examination of random plasma 
      urine samples collected from patients attending a drug-addiction clinic revealed 
      the presence of measurable amounts of cannabinoids in several of them.
FAU - Teale, J D
AU  - Teale JD
FAU - Forman, E J
AU  - Forman EJ
FAU - King, L J
AU  - King LJ
FAU - Marks, V
AU  - Marks V
LA  - eng
PT  - Journal Article
PL  - England
TA  - Lancet
JT  - Lancet (London, England)
JID - 2985213R
RN  - 0 (Antibodies)
RN  - 0 (Immune Sera)
RN  - 7J8897W37S (Dronabinol)
SB  - IM
MH  - Animals
MH  - Antibodies/isolation & purification
MH  - Blood Specimen Collection
MH  - Cannabis/*analysis
MH  - Dronabinol/administration & dosage/*analysis/blood/immunology/urine
MH  - Humans
MH  - Immune Sera
MH  - Injections, Intravenous
MH  - Rabbits
MH  - Radioimmunoassay/*methods
MH  - Sheep/immunology
MH  - Specimen Handling
EDAT- 1974/09/07 00:00
MHDA- 1974/09/07 00:01
CRDT- 1974/09/07 00:00
PHST- 1974/09/07 00:00 [pubmed]
PHST- 1974/09/07 00:01 [medline]
PHST- 1974/09/07 00:00 [entrez]
AID - S0140-6736(74)91878-9 [pii]
AID - 10.1016/s0140-6736(74)91878-9 [doi]
PST - ppublish
SO  - Lancet. 1974 Sep 7;2(7880):553-5. doi: 10.1016/s0140-6736(74)91878-9.