PMID- 417686
OWN - NLM
STAT- MEDLINE
DCOM- 19780628
LR  - 20120112
IS  - 0003-9780 (Print)
IS  - 0003-9780 (Linking)
VI  - 231
IP  - 2
DP  - 1978 Feb
TI  - Electro-acupuncture analgesia in monkeys: a behavioral and neurophysiological 
      assessment.
PG  - 274-84
AB  - Monkeys were initially trained to press a lever to escape noxious electrical 
      stimulation applied to one leg. They were then presented with electrical stimuli 
      consisting of 40 successive intensity increments beginning at zero intensity and 
      with random interstimulus intervals (ISIs). A lever press, initiated by the 
      monkey during presentation of a stimulus, immediately terminated stimulation of 
      the leg, triggering another sequence of the same increasing stimuli with a new 
      series of ISIs. After establishment of a stable threshold measure of lever 
      pressing, 45 min of electro-acupuncture was applied to traditional points on both 
      legs. The results show that electro-acupuncture dramatically increased (300-400 
      %) the lever pressing threshold for approximately 20 min after 
      electro-acupuncture stimulation was terminated. In acute monkey preparations, 
      spike activity of single neurons in N. Parafascicularis of the thalamus, evoked 
      by noxious electrical stimulation to the sciatic nerve, was recorded. The evoked 
      activity of only nociceptive specific neurons was either eliminated or markedly 
      reduced for at least one hour following 45 min of electro-acupuncture applied to 
      traditional points on both legs. The observations made by these two experimental 
      approaches suggest that electro-acupuncture exerts an analgesic effect on 
      artificially induced nociception.
FAU - Sandrew, B B
AU  - Sandrew BB
FAU - Yang, R C Jr
AU  - Yang RC Jr
FAU - Wang, S C
AU  - Wang SC
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Belgium
TA  - Arch Int Pharmacodyn Ther
JT  - Archives internationales de pharmacodynamie et de therapie
JID - 0405353
SB  - IM
MH  - *Acupuncture Therapy/methods
MH  - *Analgesia
MH  - Animals
MH  - *Behavior, Animal
MH  - Electric Stimulation
MH  - Evoked Potentials
MH  - Haplorhini
MH  - Macaca
MH  - Neurons/physiology
MH  - Pain/physiopathology
MH  - Sciatic Nerve/physiology
MH  - Thalamus/cytology/physiology
EDAT- 1978/02/01 00:00
MHDA- 2001/03/28 10:01
CRDT- 1978/02/01 00:00
PHST- 1978/02/01 00:00 [pubmed]
PHST- 2001/03/28 10:01 [medline]
PHST- 1978/02/01 00:00 [entrez]
PST - ppublish
SO  - Arch Int Pharmacodyn Ther. 1978 Feb;231(2):274-84.