PMID- 421317
OWN - NLM
STAT- MEDLINE
DCOM- 19790524
LR  - 20190623
IS  - 0009-7322 (Print)
IS  - 0009-7322 (Linking)
VI  - 59
IP  - 4
DP  - 1979 Apr
TI  - Ventricular premature contractions: a randomized non-drug intervention trial in 
      normal men.
PG  - 762-9
AB  - The influence of a 6-week intervention on factors thought to be related to 
      ectopic cardiac rhythms was tested in normal men with frequent ventricular 
      premature contractions (VPCs), using a randomized, controlled and partial 
      crossover design. The VPC intervention trial experimental regimen included total 
      abstinence from caffeine and smoking, reduction of alcohol intake, and a physical 
      conditioning program. Effects were studied in detail among 81 healthy men with 
      persistent VPCs. VPCs were measured during standard states of rest, dynamic and 
      isometric exercise and other stresses, and 24-hour ambulatory monitoring. 
      Adherence to the treatment was excellent. The experimental group achieved more 
      than 80% of activities asked of them, and little "contamination" occurred in the 
      control group. VPCs were analyzed according to VPC/min, VPC/man and VPC/total 
      number of heart beats. Moderate changes in VPC rates occurred in both 
      experimental and control groups but no significant group differences were found 
      at rest or during any induction test. This 6-week, multiple-factor "hygienic" 
      intervention program had no significant influence on the frequency or occurrence 
      of VPCs in apparently normal men with persistent and frequent VPCs. Because the 
      mechanisms and the significance of VPCs are different in patients with ischemic 
      heart disease, our approach and methods may be useful for similar trials among 
      cardiac patients of adjunct or non-drug therapy for ectopic rhythms.
FAU - DeBacker, G
AU  - DeBacker G
FAU - Jacobs, D
AU  - Jacobs D
FAU - Prineas, R
AU  - Prineas R
FAU - Crow, R
AU  - Crow R
FAU - Vilandre, J
AU  - Vilandre J
FAU - Kennedy, H
AU  - Kennedy H
FAU - Blackburn, H
AU  - Blackburn H
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Circulation
JT  - Circulation
JID - 0147763
SB  - IM
MH  - Adult
MH  - Behavior
MH  - Electrocardiography
MH  - Exercise Test
MH  - Humans
MH  - Isometric Contraction
MH  - Male
MH  - *Myocardial Contraction
MH  - Time Factors
EDAT- 1979/04/01 00:00
MHDA- 1979/04/01 00:01
CRDT- 1979/04/01 00:00
PHST- 1979/04/01 00:00 [pubmed]
PHST- 1979/04/01 00:01 [medline]
PHST- 1979/04/01 00:00 [entrez]
AID - 10.1161/01.cir.59.4.762 [doi]
PST - ppublish
SO  - Circulation. 1979 Apr;59(4):762-9. doi: 10.1161/01.cir.59.4.762.