PMID- 4355279
OWN - NLM
STAT- MEDLINE
DCOM- 19731214
LR  - 20190508
IS  - 0022-1007 (Print)
IS  - 1540-9538 (Electronic)
IS  - 0022-1007 (Linking)
VI  - 138
IP  - 4
DP  - 1973 Oct 1
TI  - Lymphocyte activation in subacute sclerosing panencephalitis virus and 
      cytomegalovirus infections. In vitro stimulation in response to viral-infected 
      cell lines.
PG  - 839-46
AB  - Efforts to stimulate lymphocytes from measles seropositive and two patients with 
      subacute sclerosing panencephalitis (SSPE) with either commercially available 
      measles virus or virus isolated from a known case of SSPE failed to show any 
      significant data using a microculture assay. Similar results were obtained using 
      lymphocytes from two patients with active cytomegalovirus (CMV) infections and 
      CMV seropositive individuals using CMV suspensions. On the other hand, 
      lymphocytes from the patients with subacute sclerosing panencephalitis exhibited 
      in vitro blastogenesis in culture with SSPE virus-infected HeLa cells. Similarly, 
      lymphocytes from the CMV-infected patients demonstrated blastogenesis when 
      cocultivated with CMV-infected WI-38 cells. This affords a new method for 
      determining the cell-mediated immune capacity of patients with "slow" virus 
      diseases.
FAU - Thurman, G B
AU  - Thurman GB
FAU - Ahmed, A
AU  - Ahmed A
FAU - Strong, D M
AU  - Strong DM
FAU - Knudsen, R C
AU  - Knudsen RC
FAU - Grace, W R
AU  - Grace WR
FAU - Sell, K W
AU  - Sell KW
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Exp Med
JT  - The Journal of experimental medicine
JID - 2985109R
RN  - 0 (Macrophage Migration-Inhibitory Factors)
RN  - 10028-17-8 (Tritium)
RN  - VC2W18DGKR (Thymidine)
SB  - IM
MH  - Animals
MH  - *Antibody Formation
MH  - Cell Line
MH  - Cytomegalovirus/*immunology
MH  - Cytomegalovirus Infections/*immunology
MH  - HeLa Cells/immunology
MH  - Humans
MH  - Immunity, Cellular
MH  - Lymphocyte Activation
MH  - Lymphocytes/*immunology
MH  - Macrophage Migration-Inhibitory Factors/analysis
MH  - Macrophages/immunology
MH  - Measles virus/*immunology
MH  - Mice
MH  - Subacute Sclerosing Panencephalitis/*immunology
MH  - Thymidine/metabolism
MH  - Tritium
PMC - PMC2180568
EDAT- 1973/10/01 00:00
MHDA- 1973/10/01 00:01
PMCR- 1974/04/01
CRDT- 1973/10/01 00:00
PHST- 1973/10/01 00:00 [pubmed]
PHST- 1973/10/01 00:01 [medline]
PHST- 1973/10/01 00:00 [entrez]
PHST- 1974/04/01 00:00 [pmc-release]
AID - 10.1084/jem.138.4.839 [doi]
PST - ppublish
SO  - J Exp Med. 1973 Oct 1;138(4):839-46. doi: 10.1084/jem.138.4.839.