PMID- 437834
OWN - NLM
STAT- MEDLINE
DCOM- 19790716
LR  - 20181130
IS  - 0019-2805 (Print)
IS  - 1365-2567 (Electronic)
IS  - 0019-2805 (Linking)
VI  - 36
IP  - 2
DP  - 1979 Feb
TI  - The metabolism of nucleic acids in mice.
PG  - 323-9
AB  - The metabolism of three forms of nucleic acid, native-DNA (N-DNA), single strand 
      DNA (SS-DNA), and polyinosinic-polycytidylic acid (poly I : C), was investigated 
      in vivo in randomly bred Swiss-Webster mice. Clearance of these substances from 
      the circulation and tissue localization were determined at selected time 
      intervals following the intravenous injection of 125I-labelled compounds. N- and 
      ss-DNA were removed from the circulation more rapidly than was poly I : C. All 
      three materials localized principally in reticuloendothelial-rich organs, i.e. 
      liver and spleen. N-DNA was degraded by the liver more slowly than was poly I : C 
      or ss-DNA. At 4 h following injection, the liver contained 26%, 13%, and 10% of 
      the injected doses, respectively. Three days after injection, 4.5% of the N-DNA 
      persisted in the liver, as compared to only 0.6% of the poly I : C, and 0.2% of 
      the ss-DNA. The possiblity that these differences in metabolism of N-DNA, poly I: 
      C, and ss-DNA may be related to their differing immunogenic potentials in 
      experimental systems is discussed.
FAU - Chia, D
AU  - Chia D
FAU - Dorsch, C A
AU  - Dorsch CA
FAU - Levy, L
AU  - Levy L
FAU - Barnett, E V
AU  - Barnett EV
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - Immunology
JT  - Immunology
JID - 0374672
RN  - 0 (DNA, Single-Stranded)
RN  - 9007-49-2 (DNA)
RN  - O84C90HH2L (Poly I-C)
SB  - IM
MH  - Animals
MH  - DNA/*metabolism
MH  - DNA, Single-Stranded/metabolism
MH  - Gastric Mucosa/metabolism
MH  - Liver/metabolism
MH  - Male
MH  - Metabolic Clearance Rate
MH  - Mice
MH  - Molecular Weight
MH  - Poly I-C/*metabolism
MH  - Spleen/metabolism
MH  - Tissue Distribution
PMC - PMC1457485
EDAT- 1979/02/01 00:00
MHDA- 1979/02/01 00:01
PMCR- 1980/02/01
CRDT- 1979/02/01 00:00
PHST- 1979/02/01 00:00 [pubmed]
PHST- 1979/02/01 00:01 [medline]
PHST- 1979/02/01 00:00 [entrez]
PHST- 1980/02/01 00:00 [pmc-release]
PST - ppublish
SO  - Immunology. 1979 Feb;36(2):323-9.