PMID- 4381636
OWN - NLM
STAT- MEDLINE
DCOM- 19670722
LR  - 20210526
IS  - 0021-9193 (Print)
IS  - 1098-5530 (Electronic)
IS  - 0021-9193 (Linking)
VI  - 93
IP  - 3
DP  - 1967 Mar
TI  - Regulation of glutamate dehydrogenases during morphogenesis of Schizophyllum 
      commune.
PG  - 904-13
AB  - The specific activities of two glutamate dehydrogenases (GDH), one requiring 
      nicotinamide adenine dinucleotide (NAD) and the other specific for nicotinamide 
      adenine dinucleotide phosphate (NADP), varied during growth of Schizophyllum 
      commune as a function of the stage of the life cycle and the exogenous nitrogen 
      source. During basidiospore germination on either glucose-NH(3) or 
      glucose-glutamate medium, NADP-GDH increased six- to eightfold in specific 
      activity, whereas NAD-GDH was depressed. During dikaryotic mycelial growth on 
      either nitrogen source, the two GDH increased in a 1:1 ratio, whereas, during 
      homokaryotic mycelial growth on glucose-NH(3), NADP-GDH activity was depressed 
      and NAD-GDH increased six- to eightfold. Homokaryotic mycelium cultured on 
      glucose-glutamate medium yielded high NADP-GDH activities and normal NAD-GDH 
      activities. Intracellular NH(3) concentration and NADP-GDH activities were 
      inversely related during spore germination and homokaryotic mycelium growth, 
      whereas guanosine-5'-triphosphate (GTP) and l-glutamine specifically inhibited 
      NAD- and NADP-GDH respectively in vitro. GTP inhibition was shown in extracts 
      from cells at all stages of the life cycle. Basidiospore germling extracts 
      contained an NADP-GDH essentially resistant to l-glutamine inhibition.
FAU - Dennen, D W
AU  - Dennen DW
FAU - Niederpruem, D J
AU  - Niederpruem DJ
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Bacteriol
JT  - Journal of bacteriology
JID - 2985120R
RN  - 0 (Guanine Nucleotides)
RN  - 0RH81L854J (Glutamine)
RN  - 0U46U6E8UK (NAD)
RN  - 53-59-8 (NADP)
RN  - 7664-41-7 (Ammonia)
RN  - EC 1.4.1.2 (Glutamate Dehydrogenase)
SB  - IM
MH  - Ammonia/metabolism
MH  - Basidiomycota/*enzymology/*growth & development
MH  - Cell Differentiation
MH  - Glutamate Dehydrogenase/*metabolism
MH  - Glutamine/pharmacology
MH  - Guanine Nucleotides/pharmacology
MH  - NAD
MH  - NADP
MH  - Spores
PMC - PMC276534
EDAT- 1967/03/01 00:00
MHDA- 1967/03/01 00:01
PMCR- 1967/03/01
CRDT- 1967/03/01 00:00
PHST- 1967/03/01 00:00 [pubmed]
PHST- 1967/03/01 00:01 [medline]
PHST- 1967/03/01 00:00 [entrez]
PHST- 1967/03/01 00:00 [pmc-release]
AID - 10.1128/jb.93.3.904-913.1967 [doi]
PST - ppublish
SO  - J Bacteriol. 1967 Mar;93(3):904-13. doi: 10.1128/jb.93.3.904-913.1967.