PMID- 45404
OWN - NLM
STAT- MEDLINE
DCOM- 19811025
LR  - 20190918
IS  - 0162-3109 (Print)
IS  - 0162-3109 (Linking)
VI  - 1
IP  - 4
DP  - 1979 Jul
TI  - Lymphocytotoxicity and immunosuppression by organotin compounds. Suppression of 
      graft-versus-host reactivity, blast transformation, and E-rosette formation by 
      di-n-butyltindichloride and di-n-octyltindichloride.
PG  - 343-55
AB  - Di-n-butyltindichloride (DBTC) and di-n-octyltindichloride (DOTC) represent a new 
      group of organometallic compounds with antilymphocytic properties. In rats they 
      induce lymphocyte depletion in thymus and thymus-dependent areas of spleen and 
      peripheral lymph nodes without signs of myelotoxicity or a generalized toxicity. 
      The number and viability of cells isolated from thymus and peripheral lymphoid 
      organs was severely decreased, whereas the number and viability of bone marrow 
      cells was not reduced. Immunosuppressive properties of DBTC and DOTC are 
      indicated, in this study, by a severe decrease of the graft-versus-host response 
      and the response to the T-cell mitogens phytohemagglutinin and concanavalin A. 
      The T-cell selectivity of these compounds is discussed. In vitro DBTC and DTOC 
      are extremely cytotoxic. Blast transformation of human as well as rat thymocytes 
      was already inhibited at concentrations as low as 0.02 micrograms DBTC (or 0.1 
      micrograms DOTC) ml medium. Also the E-rosette formation was inhibited at very 
      low drug levels. The similarity of effects upon rat and human lymphocytes 
      suggests that DBTC and DOTC acts in the same manner in rat and man and offers the 
      possibility of a therapeutic use of these compounds.
FAU - Seinen, W
AU  - Seinen W
FAU - Vos, J G
AU  - Vos JG
FAU - Brands, R
AU  - Brands R
FAU - Hooykaas, H
AU  - Hooykaas H
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Netherlands
TA  - Immunopharmacology
JT  - Immunopharmacology
JID - 7902474
RN  - 0 (Organotin Compounds)
SB  - IM
MH  - Animals
MH  - Cell Count
MH  - Cytotoxicity, Immunologic/drug effects
MH  - Graft vs Host Reaction/*drug effects
MH  - Humans
MH  - Lymphocyte Activation/*drug effects
MH  - Lymphoid Tissue/cytology
MH  - Organotin Compounds/*pharmacology
MH  - Rats
MH  - Rosette Formation
MH  - Species Specificity
MH  - T-Lymphocytes/immunology
MH  - Thymus Gland/cytology
EDAT- 1979/07/01 00:00
MHDA- 1979/07/01 00:01
CRDT- 1979/07/01 00:00
PHST- 1979/07/01 00:00 [pubmed]
PHST- 1979/07/01 00:01 [medline]
PHST- 1979/07/01 00:00 [entrez]
AID - 0162-3109(79)90031-6 [pii]
AID - 10.1016/0162-3109(79)90031-6 [doi]
PST - ppublish
SO  - Immunopharmacology. 1979 Jul;1(4):343-55. doi: 10.1016/0162-3109(79)90031-6.