PMID- 455578
OWN - NLM
STAT- MEDLINE
DCOM- 19790925
LR  - 20190827
IS  - 0344-5704 (Print)
IS  - 0344-5704 (Linking)
VI  - 2
IP  - 3
DP  - 1979
TI  - Reduction of glutathione levels in livers of mice treated with N,N'-bis 
      (2-chloroethyl)-N-nitrosourea.
PG  - 221-3
AB  - N-methyl-N-nitrosourea (MNU), 
      N-(2-chloroethyl)-N'-(trans-4-methylcyclohexyl)-N-nitrosourea (methylCCNU), and 
      N,N'-bis(2-chloroethyl)-N-nitrosourea (BCNU) were examined for their effect on 
      glutathione (GSH) levels of various tissues of normal and L1210-leukemic mice. 
      BCNU produced significant decreases in the GSH levels of livers of both groups, 
      but caused no change in the GSH content of the L1210 tumor or in the lungs. The 
      GSH content of the kidneys of L1210 tumor-bearing mice, however, was 
      significantly decreased by BCNU at early time points. A small increase in the 
      liver content of oxidized glutathione could not account for the decrease content 
      of GSH. Methyl CCNU and MNU were without effect on any of the tissues examined. 
      These data are consistent with our previous observation that BCNU is a substrate 
      for GSH S-transferase, and suggest that a GSH-dependent process is an important 
      pathway for the metabolism of BCNU.
FAU - McConnell, W R
AU  - McConnell WR
FAU - Kari, P
AU  - Kari P
FAU - Hill, D L
AU  - Hill DL
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Germany
TA  - Cancer Chemother Pharmacol
JT  - Cancer chemotherapy and pharmacology
JID - 7806519
RN  - EC 1.8.1.7 (Glutathione Reductase)
RN  - GAN16C9B8O (Glutathione)
RN  - U68WG3173Y (Carmustine)
SB  - IM
MH  - Animals
MH  - Carmustine/*pharmacology
MH  - Glutathione/*metabolism
MH  - Glutathione Reductase/metabolism
MH  - Leukemia L1210/metabolism
MH  - Liver/drug effects/enzymology/*metabolism
MH  - Male
MH  - Mice
EDAT- 1979/01/01 00:00
MHDA- 1979/01/01 00:01
CRDT- 1979/01/01 00:00
PHST- 1979/01/01 00:00 [pubmed]
PHST- 1979/01/01 00:01 [medline]
PHST- 1979/01/01 00:00 [entrez]
AID - 10.1007/BF00258299 [doi]
PST - ppublish
SO  - Cancer Chemother Pharmacol. 1979;2(3):221-3. doi: 10.1007/BF00258299.