PMID- 4597708
OWN - NLM
STAT- MEDLINE
DCOM- 19740718
LR  - 20210526
IS  - 0066-4804 (Print)
IS  - 1098-6596 (Electronic)
IS  - 0066-4804 (Linking)
VI  - 3
IP  - 1
DP  - 1973 Jan
TI  - Susceptibility of Nocardia asteroides to 45 antimicrobial agents in vitro.
PG  - 1-8
AB  - A method for preparing uniformly dispersed cultures of Nocardia asteroides for 
      use in tests for susceptibility to antimicrobial agents is described. The minimal 
      inhibiting concentration (MIC) of 45 agents for cultures thus prepared was 
      determined with the use of a replica-inoculating apparatus. Minocycline at a 
      concentration of 3.1 mug or less/ml inhibited 90% of the strains tested, and all 
      were inhibited by 6.3 mug/ml. An erythromycin concentration of 0.8 mug or less/ml 
      inhibited 40% of the strains, but the MIC for most of the others was > 100 
      mug/ml. The other agents were generally less active. Chemically related analogues 
      varied in activity to different degrees. Also, the MIC of each antibiotic against 
      different strains generally varied over a wide range. Sulfonamides and 
      trimethoprim were not active against most strains in the method used. The size of 
      the inoculum markedly affected the MIC of sulfonamides and had variable effects 
      on other agents. Marked synergy of erythromycin with ampicillin was demonstrated 
      for nearly all strains tested.
FAU - Bach, M C
AU  - Bach MC
FAU - Sabath, L D
AU  - Sabath LD
FAU - Finland, M
AU  - Finland M
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Antimicrob Agents Chemother
JT  - Antimicrobial agents and chemotherapy
JID - 0315061
RN  - 0 (Anti-Bacterial Agents)
SB  - IM
MH  - Anti-Bacterial Agents/*pharmacology
MH  - Drug Synergism
MH  - Microbial Sensitivity Tests
MH  - Nocardia asteroides/*drug effects
PMC - PMC444351
EDAT- 1973/01/01 00:00
MHDA- 1973/01/01 00:01
PMCR- 1973/01/01
CRDT- 1973/01/01 00:00
PHST- 1973/01/01 00:00 [pubmed]
PHST- 1973/01/01 00:01 [medline]
PHST- 1973/01/01 00:00 [entrez]
PHST- 1973/01/01 00:00 [pmc-release]
AID - 10.1128/AAC.3.1.1 [doi]
PST - ppublish
SO  - Antimicrob Agents Chemother. 1973 Jan;3(1):1-8. doi: 10.1128/AAC.3.1.1.