PMID- 4599860
OWN - NLM
STAT- MEDLINE
DCOM- 19740816
LR  - 20210526
IS  - 0066-4804 (Print)
IS  - 1098-6596 (Electronic)
IS  - 0066-4804 (Linking)
VI  - 5
IP  - 3
DP  - 1974 Mar
TI  - Synergistic action of ampicillin and erythromycin against Nocardia asteroides: 
      effect of time of incubation.
PG  - 344-53
AB  - Ampicillin and erythromycin were shown to act synergistically in vitro against 
      the majority of strains of Nocardia asteroides tested. With these strains, the 
      minimal inhibiting concentration (MIC) of each drug when combined was reduced 4- 
      to more than 512-fold as compared with the MIC of each antibiotic acting 
      individually against the same strains. The combined action against other strains 
      was at least additive, and occasionally indifferent, but antagonism was not 
      observed. The duration of incubation greatly influenced the MIC of erythromycin 
      but had less effect on the action of ampicillin. Synergistic action was still 
      demonstrable, although less frequently, when the period of incubation was 
      increased from 48 to 72 h.
FAU - Finland, M
AU  - Finland M
FAU - Bach, M C
AU  - Bach MC
FAU - Garner, C
AU  - Garner C
FAU - Gold, O
AU  - Gold O
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Antimicrob Agents Chemother
JT  - Antimicrobial agents and chemotherapy
JID - 0315061
RN  - 63937KV33D (Erythromycin)
RN  - 7C782967RD (Ampicillin)
SB  - IM
MH  - Ampicillin/*pharmacology
MH  - Drug Synergism
MH  - Erythromycin/*pharmacology
MH  - Nocardia asteroides/*drug effects
MH  - Time Factors
PMC - PMC428971
EDAT- 1974/03/01 00:00
MHDA- 1974/03/01 00:01
PMCR- 1974/03/01
CRDT- 1974/03/01 00:00
PHST- 1974/03/01 00:00 [pubmed]
PHST- 1974/03/01 00:01 [medline]
PHST- 1974/03/01 00:00 [entrez]
PHST- 1974/03/01 00:00 [pmc-release]
AID - 10.1128/AAC.5.3.344 [doi]
PST - ppublish
SO  - Antimicrob Agents Chemother. 1974 Mar;5(3):344-53. doi: 10.1128/AAC.5.3.344.