PMID- 461984
OWN - NLM
STAT- MEDLINE
DCOM- 19790917
LR  - 20141120
IS  - 0034-5164 (Print)
IS  - 0034-5164 (Linking)
VI  - 24
IP  - 2
DP  - 1979 May
TI  - The effect of harmine and other monoamine oxidase inhibitors on 
      N-acetyltransferase activity.
PG  - 259-72
AB  - Prior studies indicate that the monoamine oxidase inhibitors (MAOI) harmine and 
      iproniazide inhibit N-acetyltransferase activity from liver. In this report we 
      have demonstrated that harmine and harmaline are potent inhibitors of 
      N-acetyltransferase, purified from hamster and rat liver. However, other MAOI 
      such as deprenyl, clorgyline, methysergide, cyproheptadine, phenelzine, 
      pargyline, methyltryptamine and tranylcypromine have either no effect, or only 
      trivial effects on N-acetyltransferase. There is no correlation between a 
      compound's properties as an MAO and N-acetyltransferase inhibitor. One must 
      consider the inhibitory effect of harmine and harmaline on both MAO and 
      N-acetyltransferase when evaluating the effects of these compounds on 
      physiological processes.
FAU - Wright, E E
AU  - Wright EE
FAU - Bird, J L
AU  - Bird JL
FAU - Feldman, J M
AU  - Feldman JM
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - United States
TA  - Res Commun Chem Pathol Pharmacol
JT  - Research communications in chemical pathology and pharmacology
JID - 0244734
RN  - 0 (Alkaloids)
RN  - 0 (Monoamine Oxidase Inhibitors)
RN  - 4FHH5G48T7 (Harmine)
RN  - EC 2.3.1.- (Acetyltransferases)
SB  - IM
MH  - Acetyltransferases/*metabolism
MH  - Alkaloids/*pharmacology
MH  - Animals
MH  - Cricetinae
MH  - Harmine/*pharmacology
MH  - In Vitro Techniques
MH  - Liver/drug effects/*enzymology
MH  - Mesocricetus
MH  - Mitochondria, Liver/drug effects/enzymology
MH  - Monoamine Oxidase Inhibitors/*pharmacology
MH  - Rats
EDAT- 1979/05/01 00:00
MHDA- 1979/05/01 00:01
CRDT- 1979/05/01 00:00
PHST- 1979/05/01 00:00 [pubmed]
PHST- 1979/05/01 00:01 [medline]
PHST- 1979/05/01 00:00 [entrez]
PST - ppublish
SO  - Res Commun Chem Pathol Pharmacol. 1979 May;24(2):259-72.