PMID- 461993
OWN - NLM
STAT- MEDLINE
DCOM- 19790917
LR  - 20131121
IS  - 0034-5164 (Print)
IS  - 0034-5164 (Linking)
VI  - 24
IP  - 2
DP  - 1979 May
TI  - Hydrolysis of 11-palmitoyloxy-delta 9-tetrahydrocannabinol to 11-hydroxy-delta 
      9-tetrahydrocannabinol by cholesterol esterase and a lipase.
PG  - 393-6
AB  - 11-Palmitoyloxy-delta 9-tetrahydrocannabinol (11-palm-delta 9-THC) has been 
      identified in the rat in our laboratory as a long-retained metabolite of delta 
      9-tetrahydrocannabinol (delta 9-THC), the active component of marihuana (Leighty, 
      1973). Although it is not known as yet if 11-palm-delta 9-THC is itself 
      psychoactive it could be hydrolyzed to active 11-hydroxy-delta 
      9-tetrahydrocannabinol (11-OH-delta 9-THC). Our in vitro studies show that 
      cholesterol esterase and a lipase can hydrolyze 11-palm-delta 9-THC to 
      11-OH-delta 9-THC.
FAU - Leighty, E G
AU  - Leighty EG
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Res Commun Chem Pathol Pharmacol
JT  - Research communications in chemical pathology and pharmacology
JID - 0244734
RN  - 7J8897W37S (Dronabinol)
RN  - EC 3.1.1.- (Carboxylic Ester Hydrolases)
RN  - EC 3.1.1.13 (Sterol Esterase)
RN  - EC 3.1.1.3 (Lipase)
SB  - IM
MH  - Animals
MH  - Carboxylic Ester Hydrolases/*metabolism
MH  - Dronabinol/*analogs & derivatives/metabolism
MH  - Hydrolysis
MH  - Lipase/*metabolism
MH  - Liver/enzymology/*metabolism
MH  - Rats
MH  - Sterol Esterase/*metabolism
MH  - Time Factors
EDAT- 1979/05/01 00:00
MHDA- 1979/05/01 00:01
CRDT- 1979/05/01 00:00
PHST- 1979/05/01 00:00 [pubmed]
PHST- 1979/05/01 00:01 [medline]
PHST- 1979/05/01 00:00 [entrez]
PST - ppublish
SO  - Res Commun Chem Pathol Pharmacol. 1979 May;24(2):393-6.