PMID- 4719665
OWN - NLM
STAT- MEDLINE
DCOM- 19730926
LR  - 20181113
IS  - 0021-9738 (Print)
IS  - 0021-9738 (Linking)
VI  - 52
IP  - 8
DP  - 1973 Aug
TI  - Neural control of counter-regulatory events during glucopenia in man.
PG  - 1841-4
AB  - The effect of autonomic denervation on the metabolic and hormonal responses 
      during intracellular glucopenia in man was investigated. 2-Deoxy-d-glucose (2 
      DG), a competitive inhibitor of glucose metabolism, was administered 
      intravenously to nine normal volunteers and to five patients, three with complete 
      cervical cord transection (C-6) and two with idiopathic orthostatic hypotension. 
      Before, during, and after a 20 min infusion of 2 DG (50 mg/kg) plasma 
      concentrations of glucose, lactate, FFA, total catecholamines, immunoreactive 
      insulin (IRI), human growth hormone (HGH), and cortisol were determined for 
      periods up to 150 min. In control subjects, the initial elevation of FFA, 
      glucose. HGH, and cortisol corresponded with the rise in total catecholamines, 
      with maximal levels attained at 60 min, lactate rose at a slower rate, reaching 
      peak levels at 150 min: although no change in IRI was noted. In contrast, 2 
      DG-induced glucopenic stress in the autonomic denervated subjects was 
      characterized by no detectable catecholamine release or significant rise in 
      glucose, FFA, lactate, or IRI. However, HGH and cortisol responses in four of the 
      five patients were of a similar or greater magnitude than controls.These studies 
      demonstrate that the integrity of the sympathoadrenomedullary axis is essential 
      for the counter-regulatory response to intracellular glucopenia in man. Cortisol 
      and HGH have no apparent role in these events.
FAU - Brodows, R G
AU  - Brodows RG
FAU - Pi-Sunyer, F X
AU  - Pi-Sunyer FX
FAU - Campbell, R G
AU  - Campbell RG
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Clin Invest
JT  - The Journal of clinical investigation
JID - 7802877
RN  - 0 (Antigens)
RN  - 0 (Blood Glucose)
RN  - 0 (Catecholamines)
RN  - 0 (Fatty Acids, Nonesterified)
RN  - 0 (Insulin)
RN  - 0 (Lactates)
RN  - 0 (Nicotinic Acids)
RN  - 9002-72-6 (Growth Hormone)
RN  - IY9XDZ35W2 (Glucose)
RN  - WI4X0X7BPJ (Hydrocortisone)
SB  - IM
MH  - Adrenal Medulla/*physiology
MH  - Adult
MH  - Antigens/analysis
MH  - Blood Glucose
MH  - Catecholamines/blood
MH  - Fatty Acids, Nonesterified/blood
MH  - Female
MH  - Glucose/administration & dosage/*metabolism
MH  - Growth Hormone/blood
MH  - Humans
MH  - Hydrocortisone/blood
MH  - Hypoglycemia/chemically induced
MH  - Injections, Intravenous
MH  - Insulin/blood
MH  - Lactates/blood
MH  - Male
MH  - Nicotinic Acids/pharmacology
MH  - Spinal Cord Injuries/metabolism
MH  - Sympathetic Nervous System/*physiology
MH  - Time Factors
PMC - PMC302464
EDAT- 1973/08/01 00:00
MHDA- 1973/08/01 00:01
PMCR- 1973/08/01
CRDT- 1973/08/01 00:00
PHST- 1973/08/01 00:00 [pubmed]
PHST- 1973/08/01 00:01 [medline]
PHST- 1973/08/01 00:00 [entrez]
PHST- 1973/08/01 00:00 [pmc-release]
AID - 10.1172/JCI107366 [doi]
PST - ppublish
SO  - J Clin Invest. 1973 Aug;52(8):1841-4. doi: 10.1172/JCI107366.