PMID- 47314
OWN - NLM
STAT- MEDLINE
DCOM- 19750619
LR  - 20190816
IS  - 0020-5915 (Print)
IS  - 0020-5915 (Linking)
VI  - 48
IP  - 4
DP  - 1975
TI  - Ontogeny of lymphoid cell surface determinants in the chicken.
PG  - 513-29
AB  - Five antigenic lymphoid cell surface determinants (LCSD) were detected in hatched 
      chickens using specific antisera. These LCSD were: thymus-specific surface 
      determinants, bursa-specific non-immunoglobulin determinants, IgM-specific 
      determants, IgG-specific determinants, and IgA-specific determinants (ASD). 
      Viable cell suspension of embryonic yolk sac, bursa, thymus and spleen were 
      tested by means of indirect or direct immunofluorescent staining procedures for 
      the presence and frequency of LCSD during maturation. Experiments performed with 
      liver cells. brain cells and red blood cells of embryos confirmed the 
      specificities of the antisera used for determinants present on cells of lymphoid 
      tissues. The results showed LCSD to occur on yolk sac cells on the 5th to 7th 
      embryonic day (ED). This suggests the presence of a stem cell pre-committed for 
      the lymphoid cell line already in the yolk sac. Furthermore, findings are 
      reported indicating the presence of distinct lympoid stem cell populations or 
      maturation stages in the yolk sac, which may be responsible for either populating 
      the thymus or the bursa. The finding of ASD-bearing cells early in ontogenesis of 
      the lymphoid system suggests the presence of two specificities in anti-chicken 
      IgA sera, one of which may be directed against an antigenic site on a rudimentary 
      immunoglobulin molecule, which becomes lost or hidden in later maturation. 
      Studies on the bursa and the thymus show that covering, hiding, or loss of 
      antigenic determinants plays an important role in lymphoid cell differentiation. 
      Furthermore, the spleen is reached by B-determined stem cells as early as the 
      bursa, but these stem cells seem not to proliferate in the former to any 
      considerable extent until hatching. Finally, the sequence of the appearance of 
      immunoglobulin classes as proposed by other authors is confirmed with 
      reservaitons concerning IgA, and it is suggested that immunoglobulins are 
      detectable earlier on cell surfaces than intracytoplasmatically.
FAU - Albini, B
AU  - Albini B
FAU - wick, G
AU  - wick G
LA  - eng
PT  - Journal Article
PL  - Switzerland
TA  - Int Arch Allergy Appl Immunol
JT  - International archives of allergy and applied immunology
JID - 0404561
RN  - 0 (Epitopes)
RN  - 0 (Immune Sera)
RN  - 0 (Immunoglobulin A)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Immunoglobulin M)
SB  - IM
MH  - Animals
MH  - B-Lymphocytes/immunology
MH  - Brain/cytology
MH  - Bursa of Fabricius/cytology/immunology
MH  - Cell Differentiation
MH  - Cell Membrane/*immunology
MH  - Chick Embryo
MH  - Chickens
MH  - *Epitopes
MH  - Erythrocytes/immunology
MH  - Female
MH  - Fluorescent Antibody Technique
MH  - Gestational Age
MH  - Immune Sera
MH  - Immunoglobulin A
MH  - Immunoglobulin G
MH  - Immunoglobulin M
MH  - Liver/cytology
MH  - Lymphocytes/*immunology
MH  - Rabbits/immunology
MH  - Spleen/cytology
MH  - Thymus Gland/cytology/immunology
MH  - Turkeys/immunology
MH  - Vitelline Membrane/cytology
EDAT- 1975/01/01 00:00
MHDA- 1975/01/01 00:01
CRDT- 1975/01/01 00:00
PHST- 1975/01/01 00:00 [pubmed]
PHST- 1975/01/01 00:01 [medline]
PHST- 1975/01/01 00:00 [entrez]
AID - 10.1159/000231339 [doi]
PST - ppublish
SO  - Int Arch Allergy Appl Immunol. 1975;48(4):513-29. doi: 10.1159/000231339.