PMID- 4783093
OWN - NLM
STAT- MEDLINE
DCOM- 19740507
LR  - 20230310
IS  - 0022-3751 (Print)
IS  - 1469-7793 (Electronic)
IS  - 0022-3751 (Linking)
VI  - 231
IP  - 3
DP  - 1973 Jun
TI  - Intracellular recording from the myenteric plexus of the guinea-pig ileum.
PG  - 471-91
AB  - 1. Ganglion cells of the myenteric plexus of the guinea-pig ileum have been 
      studied with intracellular micro-electrodes.2. Three types of cell were 
      distinguished. Type 1 cells had a high resistance (58 MOmega) and had properties 
      similar to guinea-pig sympathetic ganglion cells. Type 2 cells were also 
      excitable but had a lower resistance (21 MOmega) and showed accommodation to 
      depolarizing current pulses. Type 3 cells were inexcitable.3. Point stimulation 
      within 150 mum excited neurones either antidromically or orthodromically, 
      sometimes both.4. Antidromic responses had a small all-or-nothing component which 
      was subthreshold for the soma spike. Two or more such components sometimes 
      occurred, and were probably due to stimulation of two or more cell processes.5. 
      Excitatory post-synaptic potentials (e.p.s.p.s) were blocked by hexamethonium 
      (400 muM). They progressively declined in amplitude when elicited at frequencies 
      of 0.05 Hz or more, and this is discussed in relation to studies on acetylcholine 
      (ACh) output.6. Many cells often showed a slow after-hyperpolarization following 
      a direct or antidromic spike. Its mechanism and significance are discussed.7. 
      Spontaneous e.p.s.p.s and spikes were occasionally seen.8. Intracellular 
      injection of a fluorescent dye reveals that the neurones have one to seven 
      processes, which usually arise from the poles of the oval soma.
FAU - Nishi, S
AU  - Nishi S
FAU - North, R A
AU  - North RA
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Physiol
JT  - The Journal of physiology
JID - 0266262
RN  - 0 (Fluorescent Dyes)
RN  - 0 (Hexamethonium Compounds)
RN  - N9YNS0M02X (Acetylcholine)
SB  - IM
MH  - Acetylcholine/metabolism
MH  - Action Potentials
MH  - Animals
MH  - Electric Stimulation
MH  - Electrophysiology
MH  - Fluorescent Dyes/analysis
MH  - Guinea Pigs
MH  - Hexamethonium Compounds/pharmacology
MH  - Ileum/*innervation
MH  - Myenteric Plexus/*cytology/physiology
MH  - Neurons/cytology/*physiology
MH  - Synapses/physiology
PMC - PMC1350675
EDAT- 1973/06/01 00:00
MHDA- 1973/06/01 00:01
PMCR- 1974/06/01
CRDT- 1973/06/01 00:00
PHST- 1973/06/01 00:00 [pubmed]
PHST- 1973/06/01 00:01 [medline]
PHST- 1973/06/01 00:00 [entrez]
PHST- 1974/06/01 00:00 [pmc-release]
AID - 10.1113/jphysiol.1973.sp010244 [doi]
PST - ppublish
SO  - J Physiol. 1973 Jun;231(3):471-91. doi: 10.1113/jphysiol.1973.sp010244.