PMID- 485758
OWN - NLM
STAT- MEDLINE
DCOM- 19791129
LR  - 20061115
IS  - 0003-9926 (Print)
IS  - 0003-9926 (Linking)
VI  - 139
IP  - 10
DP  - 1979 Oct
TI  - Idiopathic hypothalamic hypogonadotropic hypogonadism with polyostotic fibrous 
      dysplasia.
PG  - 1187-9
AB  - A 22-year-old woman had polyostotic fibrous dysplasia (POFD) and idiopathic 
      hypothalamic hypogonadotropic hypogonadism (isolated gonadotropin deficiency). 
      Recurrent fracture of dysplastic bone during childhood was associated with 
      primary amenorrhea, clinical and laboratory evidence of estrogen deficiency, and 
      subnormal circulating and urinary gonadotropin levels during adolescence. 
      Gonadorelin (luteinizing hormone-releasing hormone) stimulation initially showed 
      a luteinizing hormone (LH) response but absent follicle-stimulating hormone (FSH) 
      response. After three months without estrogen and progesterone and after four 
      days of gonadorelin "priming," a subsequent gonadorelin infusion produced an 
      enhanced LH and FSH response. All other tests of peripheral and trophic hormone 
      levels and pituitary trophic hormone reserves were normal. Whereas POFD is known 
      to occur with sexual precocity and other endocrinopathies, to our knowledge this 
      is the first report of its association with isolated gonadotropin deficiency.
FAU - Shires, R
AU  - Shires R
FAU - Whyte, M P
AU  - Whyte MP
FAU - Avioli, L V
AU  - Avioli LV
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Arch Intern Med
JT  - Archives of internal medicine
JID - 0372440
RN  - 0 (Gonadotropins, Pituitary)
SB  - IM
MH  - Adult
MH  - Amenorrhea/etiology
MH  - Female
MH  - Fibrous Dysplasia of Bone/*complications
MH  - Fibrous Dysplasia, Polyostotic/*complications/diagnosis
MH  - Gonadotropins, Pituitary/*deficiency
MH  - Humans
MH  - Hypogonadism/diagnosis/*etiology
MH  - Hypothalamo-Hypophyseal System/*physiopathology
EDAT- 1979/10/01 00:00
MHDA- 1979/10/01 00:01
CRDT- 1979/10/01 00:00
PHST- 1979/10/01 00:00 [pubmed]
PHST- 1979/10/01 00:01 [medline]
PHST- 1979/10/01 00:00 [entrez]
PST - ppublish
SO  - Arch Intern Med. 1979 Oct;139(10):1187-9.