PMID- 49141
OWN - NLM
STAT- MEDLINE
DCOM- 19750829
LR  - 20131121
IS  - 0001-5598 (Print)
IS  - 0001-5598 (Linking)
VI  - 79
IP  - 2
DP  - 1975 Jun
TI  - In vivo uptake and metabolism of 3-h-5alpha-androstane-3alpha,17beta-diol and of 
      3-h-5alpha-androstane-3beta,17beta-diol by human prostatic hypertrophy.
PG  - 394-402
AB  - Tritiated 5alpha-androstane-3alpha,17beta-diol (3alpha-diol) and 
      5alpha-androstane-3beta,17beta-diol (3beta-diol) respectively were administered 
      to patients with benign prostatic hypertrophy (bph) undergoing prostatectomy. In 
      prostate and skeletal muscle homogenates and in plasma the total radioactivity 
      content as well as the formation of metabolites were measured. Histological 
      examination of each ectomized prostate was performed to evaluate the cellular 
      composition of the tissue. After 3alpha-diol injection, a higher uptake of 
      radioactivity in the prostate was obtained than after 3beta-diol. Within 30 min 
      the 3alpha-isomer was very efficiently converted to 5alpha-DHT, while most of the 
      3beta-isomer remained unchanged. There was, however, also after administration of 
      the 3beta-diol a substantial biconversion to 5alpha-DHT as has been confirmed by 
      recrystallization to constant specific radioactivity. Only after 3beta-diol 
      epiandrosterone was detected in small but significant amounts. 3alpha-diol 
      administration resulted in distinct concentrations of 3beta-diol, whereas the 
      conversion of 3beta-diol to the 3alpha-isomer was insignificant. When comparing 
      the histological composition of the prostatic tissue with the accumulation of 
      radioactivity and the formation of metabolites only a weak correlation between 
      glandular structure and radioactivity uptake after 3alpha-diol administration 
      could be revealed.
FAU - Horst, H J
AU  - Horst HJ
FAU - Dennis, M
AU  - Dennis M
FAU - Kaufmann, J
AU  - Kaufmann J
FAU - Voigt, K D
AU  - Voigt KD
LA  - eng
PT  - Journal Article
PL  - Denmark
TA  - Acta Endocrinol (Copenh)
JT  - Acta endocrinologica
JID - 0370312
RN  - 0 (Androstanes)
RN  - 08J2K08A3Y (Dihydrotestosterone)
RN  - 10028-17-8 (Tritium)
RN  - 25126-76-5 (Androstane-3,17-diol)
RN  - C24W7J5D5R (Androsterone)
SB  - IM
MH  - Aged
MH  - Androstane-3,17-diol/blood/*metabolism
MH  - Androstanes/*metabolism
MH  - Androsterone/biosynthesis
MH  - Dihydrotestosterone/biosynthesis
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Muscles/metabolism
MH  - Prostate/*metabolism/pathology
MH  - Prostatic Hyperplasia/blood/*metabolism/pathology
MH  - Tritium
EDAT- 1975/06/01 00:00
MHDA- 1975/06/01 00:01
CRDT- 1975/06/01 00:00
PHST- 1975/06/01 00:00 [pubmed]
PHST- 1975/06/01 00:01 [medline]
PHST- 1975/06/01 00:00 [entrez]
PST - ppublish
SO  - Acta Endocrinol (Copenh). 1975 Jun;79(2):394-402.