PMID- 5054473
OWN - NLM
STAT- MEDLINE
DCOM- 19721018
LR  - 20181113
IS  - 0021-9738 (Print)
IS  - 0021-9738 (Linking)
VI  - 51
IP  - 8
DP  - 1972 Aug
TI  - In vivo formation of H2O2 in red cells during exposure to hyperoxia.
PG  - 2211-3
AB  - Chow-fed and tocopherol-deficient mice were given aminotriazole (AT), exposed to 
      100% O(2) at 60 pounds per square inch absolute for 1 hr (OHP), and red blood 
      cells were assayed for catalase activity and lipid peroxide levels. A decrease of 
      catalase activity (CA) in the presence of AT can be taken as evidence of excess 
      formation or accumulation of H(2)O(2). No differences of CA were observed among 
      chow-fed mice, with or without AT and/or OHP. Tocopherol-deficient mice with AT 
      had lower CA (0.174+/-0.040) than chow-fed mice with AT (0.225+/-0.028) P < 0.01. 
      Tocopherol-deficient mice with AT exposed to OHP had even lower CA, 
      0.137+/-0.024, P < 0.01.The data are consistent with the hypothesis that H(2)O(2) 
      is formed or accumulated in excess in red cells of tocopherol-deficient mice, an 
      effect that is enhanced in the presence of hyperoxia. They imply that tocopherol 
      plays a role in the detoxification of H(2)O(2).
FAU - Johnson, W P
AU  - Johnson WP
FAU - Jefferson, D
AU  - Jefferson D
FAU - Mengel, C E
AU  - Mengel CE
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Clin Invest
JT  - The Journal of clinical investigation
JID - 7802877
RN  - 0 (Triazoles)
RN  - BBX060AN9V (Hydrogen Peroxide)
RN  - EC 1.11.1.6 (Catalase)
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - Animals
MH  - Catalase/metabolism
MH  - Erythrocytes/enzymology/*metabolism
MH  - Female
MH  - Hydrogen Peroxide/*biosynthesis
MH  - Hyperbaric Oxygenation
MH  - Male
MH  - Mice
MH  - Mice, Inbred Strains
MH  - Oxygen/*poisoning
MH  - Triazoles/pharmacology
MH  - Vitamin E Deficiency/blood/enzymology/*metabolism
PMC - PMC292379
EDAT- 1972/08/01 00:00
MHDA- 1972/08/01 00:01
PMCR- 1972/08/01
CRDT- 1972/08/01 00:00
PHST- 1972/08/01 00:00 [pubmed]
PHST- 1972/08/01 00:01 [medline]
PHST- 1972/08/01 00:00 [entrez]
PHST- 1972/08/01 00:00 [pmc-release]
AID - 10.1172/JCI107029 [doi]
PST - ppublish
SO  - J Clin Invest. 1972 Aug;51(8):2211-3. doi: 10.1172/JCI107029.