PMID- 531492
OWN - NLM
STAT- MEDLINE
DCOM- 19800423
LR  - 20190819
IS  - 0036-5513 (Print)
IS  - 0036-5513 (Linking)
VI  - 39
IP  - 8
DP  - 1979 Dec
TI  - Intrarenal venous and cortical catheter pressures in the dog kidney.
PG  - 697-705
AB  - To examine the validity of intrarenal venous pressure (IRVP) as a measure of 
      peritubular capillary pressure when obtained with a method applicable in man, 
      IRVP was measured with a 0.9 mm o.d. catheter introduced retrograde into 
      interlobar veins of anesthetized dogs and was compared with a modified needle 
      pressure (cortical catheter pressure = RCCP) measured simultaneously in the same 
      kidneys. In twelve dogs with a mean experimental kidney control sodium excretion 
      of 91 +/- 15 (SEM) micronmol/min IRVP averaged 16.0 +/- 1.1 mmHg and was 
      significantly lower than the average RCCP of 22.6 +/- 1.1 mmHg (P less than 
      0.001). These pressures compare well with the reported micropuncture pressures in 
      the peritubular capillaries and proximal tubules, respectively, at comparable 
      levels of sodium excretion. IRVP fell significantly during reduction of renal 
      perfusion pressure within the range of autoregulation of renal blood flow and 
      increased during elevation of renal pelvic pressure (PP). At at PP of 60 mmHg, 
      when urine flow had stopped, the PP-IRVP gradient was 22.7 +/- 3.1 and increased 
      to 36.7 +/- 3.8 (P less than 0.001) at a PP of 80. Acute renal vein constriction 
      always increased IRVP before renal vein pressure reached the preceeding control 
      level of IRVP. Increased urine flow during saline volume expansion and furosemid 
      infusion was associated with increased IRVP. The results when compared with 
      micropuncture data indicate that IRVP is a satisfactory expression of peritubular 
      capillary pressure in the experimental conditions included in the study.
FAU - Willassen, Y
AU  - Willassen Y
FAU - Ofstad, J
AU  - Ofstad J
LA  - eng
PT  - Journal Article
PL  - England
TA  - Scand J Clin Lab Invest
JT  - Scandinavian journal of clinical and laboratory investigation
JID - 0404375
RN  - 451W47IQ8X (Sodium Chloride)
RN  - 7LXU5N7ZO5 (Furosemide)
SB  - IM
MH  - Animals
MH  - Capillaries/physiology
MH  - Catheterization/instrumentation
MH  - Diuresis/drug effects
MH  - Dogs
MH  - Female
MH  - Furosemide/pharmacology
MH  - Hydrostatic Pressure
MH  - Kidney/*blood supply
MH  - Kidney Cortex/blood supply/*physiology
MH  - Male
MH  - Microcirculation/physiology
MH  - Pressure
MH  - Renal Veins/*physiology
MH  - Sodium Chloride/pharmacology
MH  - Vascular Resistance/drug effects
MH  - *Venous Pressure/drug effects
EDAT- 1979/12/01 00:00
MHDA- 1979/12/01 00:01
CRDT- 1979/12/01 00:00
PHST- 1979/12/01 00:00 [pubmed]
PHST- 1979/12/01 00:01 [medline]
PHST- 1979/12/01 00:00 [entrez]
AID - 10.1080/00365517909108160 [doi]
PST - ppublish
SO  - Scand J Clin Lab Invest. 1979 Dec;39(8):697-705. doi: 10.1080/00365517909108160.