PMID- 531493
OWN - NLM
STAT- MEDLINE
DCOM- 19800423
LR  - 20190819
IS  - 0036-5513 (Print)
IS  - 0036-5513 (Linking)
VI  - 39
IP  - 8
DP  - 1979 Dec
TI  - Postglomerular vascular hydrostatic and oncotic pressures during acute saline 
      volume expansion in normotensive man.
PG  - 707-15
AB  - The importance of the peritubular physical factors as mediators of the 
      natriuretic response to saline volume expansion was examined in twenty 
      normotensive, hydropenic indivduals. Intrarenal venous pressure (IRVP), used as a 
      measure of peritubular capillary hydrostatic pressure, and efferent arteriolar 
      colloid osmotic pressure, calculated from arterial colloid osmotic pressure and 
      the filtration fraction, were measured before and during sustained volume 
      expansion with 0.9% NaCl, increasing the body weight by 3% and plasma volume 
      about 20%. During expansion there was a significant increase in urine flow from 
      1.1 +/0 0.1 to 3.1 +/- 0.4 ml/min and sodium excretion from 161 +/- 12 to 551 +/- 
      61 microEq/min. Efferent colloid osmotic pressure fell from 31.9 +/- 0.6 to 23.6 
      +/- 0.5 mmHg (P less than 0.001) while IRVP changed from 24.8 +/- 0.8 to 25.1 +/- 
      0.9 mmHg (P greater than 0.10). In eight individuals IRVP increased during saline 
      loading but later fell during sustained expansion. Glomerular filtration rate and 
      renal blood flow did not change significantly. It is concluded that increase in 
      peritubular capillary hydrostatic pressure is not necessary either to induce or 
      to maintain the natriuresis of a moderate saline volume expansion. Although the 
      fall in postglomerular vascular colloid osmotic pressure is a possible mediator 
      of the natriuretic response, the change in peritubular transcapillary net driving 
      force produced by a modest saline volume expansion is probably small.
FAU - Willassen, Y
AU  - Willassen Y
FAU - Ofstad, J
AU  - Ofstad J
LA  - eng
PT  - Journal Article
PL  - England
TA  - Scand J Clin Lab Invest
JT  - Scandinavian journal of clinical and laboratory investigation
JID - 0404375
RN  - 451W47IQ8X (Sodium Chloride)
SB  - IM
MH  - Adult
MH  - Capillaries/physiology
MH  - Humans
MH  - Hydrostatic Pressure
MH  - Kidney/*blood supply/physiology
MH  - Natriuresis/drug effects
MH  - Osmotic Pressure
MH  - Renal Veins/*physiology
MH  - Sodium Chloride/pharmacology
MH  - Vascular Resistance/drug effects
MH  - *Venous Pressure/drug effects
EDAT- 1979/12/01 00:00
MHDA- 1979/12/01 00:01
CRDT- 1979/12/01 00:00
PHST- 1979/12/01 00:00 [pubmed]
PHST- 1979/12/01 00:01 [medline]
PHST- 1979/12/01 00:00 [entrez]
AID - 10.1080/00365517909108161 [doi]
PST - ppublish
SO  - Scand J Clin Lab Invest. 1979 Dec;39(8):707-15. doi: 10.1080/00365517909108161.