PMID- 53329
OWN - NLM
STAT- MEDLINE
DCOM- 19760209
LR  - 20190610
IS  - 0140-6736 (Print)
IS  - 0140-6736 (Linking)
VI  - 2
IP  - 7940
DP  - 1975 Nov 1
TI  - Clinical and serological analysis of transfusion-associated hepatitis.
PG  - 838-41
AB  - Of 108 prospectively followed, multiply transfused, open-heart-surgery patients, 
      12 (11%) developed hepatitis. Patients received only volunteer donor blood tested 
      for hepatitis-B surface antigen (HBsAg) prior to transfusion by 
      counterelectrophoresis (C.E.P.). 4 of the 12 patients developed hepatitis-B-virus 
      infection. Subsequent testing of donor serums by solid-phase radioimmunoassay 
      (R.I.A.) revealed that an R.I.A.-positive, C.E.P.-negative blood unit was 
      transfused to 3 of the 4 type-B hepatitis cases, but to none of the remaining 104 
      patients; 3 hepatitis-B cases could probably have been prevented by prescreening 
      of donors by solid-phase R.I.A. 8 hepatitis cases were serologically unrelated to 
      the hepatitis-B virus, the hepatitis-A virus, the cytomegalovirus, or the 
      Epstein-Barr virus. Had R.I.A.-positive donors been excluded, 8 of the 9 residual 
      hepatitis cases (89%) would have represented "non-A, non-B" hepatitis. The 
      existence of previously unrecognised human hepatitis virus(es) is probable.
FAU - Alter, H J
AU  - Alter HJ
FAU - Holland, P V
AU  - Holland PV
FAU - Morrow, A G
AU  - Morrow AG
FAU - Purcell, R H
AU  - Purcell RH
FAU - Feinstone, S M
AU  - Feinstone SM
FAU - Moritsugu, Y
AU  - Moritsugu Y
LA  - eng
PT  - Journal Article
PL  - England
TA  - Lancet
JT  - Lancet (London, England)
JID - 2985213R
RN  - 0 (Antibodies, Viral)
RN  - 0 (Hepatitis B Antigens)
RN  - EC 2.6.1.1 (Aspartate Aminotransferases)
RN  - EC 2.6.1.2 (Alanine Transaminase)
RN  - RFM9X3LJ49 (Bilirubin)
SB  - IM
MH  - Adult
MH  - Alanine Transaminase/blood
MH  - Antibodies, Viral/isolation & purification
MH  - Aspartate Aminotransferases/blood
MH  - Bilirubin/blood
MH  - Blood Donors
MH  - Blood Specimen Collection
MH  - Cytomegalovirus/immunology
MH  - Hemagglutination Tests
MH  - Hepatitis B/blood/*diagnosis/etiology
MH  - Hepatitis B Antigens/isolation & purification
MH  - Hepatitis B virus/immunology
MH  - Hepatovirus/immunology
MH  - Herpesvirus 4, Human/immunology
MH  - Humans
MH  - Prospective Studies
MH  - Radioimmunoassay
MH  - *Transfusion Reaction
EDAT- 1975/11/01 00:00
MHDA- 1975/11/01 00:01
CRDT- 1975/11/01 00:00
PHST- 1975/11/01 00:00 [pubmed]
PHST- 1975/11/01 00:01 [medline]
PHST- 1975/11/01 00:00 [entrez]
AID - S0140-6736(75)90234-2 [pii]
AID - 10.1016/s0140-6736(75)90234-2 [doi]
PST - ppublish
SO  - Lancet. 1975 Nov 1;2(7940):838-41. doi: 10.1016/s0140-6736(75)90234-2.