PMID- 537247
OWN - NLM
STAT- MEDLINE
DCOM- 19800523
LR  - 20190725
IS  - 0021-5198 (Print)
IS  - 0021-5198 (Linking)
VI  - 29
IP  - 2
DP  - 1979 Apr
TI  - Femoral vascular responses to purine and pyrimidine derivatives: release of 
      5-hydroxytryptamine by purine derivatives in isolated, cross-circulated rat 
      hindlimb.
PG  - 243-51
AB  - The mode of actions of the purines, adenosine, adenosine-5'-triphosphate (ATP), 
      guanosine and guanosine-5'-triphosphate (GTP), and the pyrimidines, cytidine, 
      cytidine-5'-triphosphate (CTP), thymidine, thymidine-5'-triphosphate (TTP), 
      uridine and uridine-5'-triphosphate (UTP) was investigated in the isolated 
      hindlimb preparation of the rat. A single injection of adenosine, ATP, GTP or UTP 
      into the femoral artery induced a biphasic response, a prominent vasoconstriction 
      preceded by a transient vasodilatation, whereas guanosine and uridine caused only 
      a vasoconstriction. Cytidine, CTP, thymidine and TTP were almost ineffective on 
      the vascular bed. The vasoconstrictor responses to adenosine, ATP, guanosine and 
      GTP were effectively antagonized by either methysergide or reserpine, whereas 
      those to uridine and UTP were not modified by either methysergide or 
      phentolamine. Adenine, D-(-)-ribose and hypoxanthine had no effect on the 
      vascular bed. The 5-hydroxytryptamine (5-HT) release from the hindlimb was 
      fluorometrically determined. The present results provide direct evidence that the 
      vasoconstriction caused by ATP, adenosine, GTP and guanosine is attributed to the 
      release of 5-HT from their stores and that purine nucleotides and nucleosides are 
      capable of releasing 5-HT.
FAU - Sakai, K
AU  - Sakai K
FAU - Akima, M
AU  - Akima M
FAU - Matsushita, H
AU  - Matsushita H
LA  - eng
PT  - Journal Article
PL  - Japan
TA  - Jpn J Pharmacol
JT  - Japanese journal of pharmacology
JID - 2983305R
RN  - 0 (Purines)
RN  - 0 (Pyrimidines)
RN  - 333DO1RDJY (Serotonin)
RN  - XZA9HY6Z98 (Methysergide)
RN  - Z468598HBV (Phentolamine)
SB  - IM
MH  - Animals
MH  - Cross Circulation
MH  - Extremities/blood supply
MH  - Femoral Vein/drug effects
MH  - In Vitro Techniques
MH  - Male
MH  - Methysergide/pharmacology
MH  - Muscle, Smooth, Vascular/*drug effects
MH  - Perfusion
MH  - Phentolamine/pharmacology
MH  - Purines/*pharmacology
MH  - Pyrimidines/antagonists & inhibitors/*pharmacology
MH  - Rats
MH  - Serotonin/*metabolism
MH  - Vasoconstriction/*drug effects
EDAT- 1979/04/01 00:00
MHDA- 1979/04/01 00:01
CRDT- 1979/04/01 00:00
PHST- 1979/04/01 00:00 [pubmed]
PHST- 1979/04/01 00:01 [medline]
PHST- 1979/04/01 00:00 [entrez]
AID - 10.1254/jjp.29.243 [doi]
PST - ppublish
SO  - Jpn J Pharmacol. 1979 Apr;29(2):243-51. doi: 10.1254/jjp.29.243.