PMID- 541873
OWN - NLM
STAT- MEDLINE
DCOM- 19800627
LR  - 20190918
IS  - 0021-5112 (Print)
IS  - 0021-5112 (Linking)
VI  - 32
IP  - 2
DP  - 1979 Apr
TI  - Detection of IgG antibody to measles virus by radioimmunoassay technique.
PG  - 67-76
AB  - A highly sensitive procedure of solid-phase radioimmunoassay (RIA) was developed 
      for the detection of measles IgG antibody. HeLa cells persistently infected with 
      measles virus were used as a solid-phase antigen. This technique was applied to 
      the detection of measles IgG antibody in patients with subacute sclerosing 
      panencephalitis (SSPE) and multiple sclerosis. Normal subjects having experienced 
      natural measles or measles vaccination and patients with various neurological 
      diseases of non-virus nature were also examined as control groups. Measles 
      antibody was detected at high titers in both the sera and cerebrospinal fluid of 
      SSPE patients. Moreover, RIA/HI ratios of SSPE patients were significantly higher 
      than those of normal subjects, suggesting the presence in the formers of 
      antibodies to nucleocapsids at high titers as well as to viral envelopes. On the 
      other hand, no significant difference was found in both RIA and HI titers between 
      the sera of multiple sclerosis and those of various neurological diseases.
FAU - Sakata, H
AU  - Sakata H
FAU - Yamanouchi, K
AU  - Yamanouchi K
FAU - Machida, K
AU  - Machida K
FAU - Matsuzaki, F
AU  - Matsuzaki F
FAU - Shishido, A
AU  - Shishido A
FAU - Iwashita, H
AU  - Iwashita H
FAU - Kuroiwa, Y
AU  - Kuroiwa Y
LA  - eng
PT  - Journal Article
PL  - Japan
TA  - Jpn J Med Sci Biol
JT  - Japanese journal of medical science & biology
JID - 0243706
RN  - 0 (Antibodies, Viral)
RN  - 0 (Immunoglobulin G)
SB  - IM
MH  - Antibodies, Viral/*analysis/cerebrospinal fluid
MH  - Binding Sites
MH  - HeLa Cells
MH  - Humans
MH  - Immunoglobulin G/*analysis/cerebrospinal fluid
MH  - Measles virus/*immunology
MH  - Multiple Sclerosis/immunology
MH  - Radioimmunoassay/*methods
MH  - Subacute Sclerosing Panencephalitis/immunology
EDAT- 1979/04/01 00:00
MHDA- 1979/04/01 00:01
CRDT- 1979/04/01 00:00
PHST- 1979/04/01 00:00 [pubmed]
PHST- 1979/04/01 00:01 [medline]
PHST- 1979/04/01 00:00 [entrez]
AID - 10.7883/yoken1952.32.67 [doi]
PST - ppublish
SO  - Jpn J Med Sci Biol. 1979 Apr;32(2):67-76. doi: 10.7883/yoken1952.32.67.