PMID- 553327
OWN - NLM
STAT- MEDLINE
DCOM- 19810224
LR  - 20190902
IS  - 0163-4356 (Print)
IS  - 0163-4356 (Linking)
VI  - 1
IP  - 1
DP  - 1979
TI  - Mephobarbital and phenobarbital plasma concentrations in epileptic patients 
      treated with mephobarbital.
PG  - 117-22
AB  - Plasma mephobarbital and phenobarbital concentrations were determined in 11 
      epileptic patients receiving mephobarbital alone or in combination with other 
      antiepileptic drugs. The analysis was carried out by a selective ion monitoring 
      (SIM) mass fragmentography technique following formation of N-propyl derivatives 
      of both drugs. The plasma concentrations of phenobarbital ranged from 4 to 32 
      micrograms/ml and those of mephobarbital from 0.2 to 1.7 micrograms/ml. 
      Differences in the metabolism rates of the drugs accounted for the plasma 
      concentration differences; mephobarbital is metabolized more rapidly than 
      phenobarbital. Phenobarbital concentrations obtained by SIM mass fragmentography 
      were similar to those obtained by gas-liquid chromatographic on-column 
      methylation, which quantitates only "total phenobarbital" (mephobarbital plus 
      phenobarbital).
FAU - Kupferberg, H J
AU  - Kupferberg HJ
FAU - Longacre-Shaw, J
AU  - Longacre-Shaw J
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Ther Drug Monit
JT  - Therapeutic drug monitoring
JID - 7909660
RN  - 5NC67NU76B (Mephobarbital)
RN  - YQE403BP4D (Phenobarbital)
SB  - IM
MH  - Chromatography, Gas
MH  - Epilepsy/*drug therapy
MH  - Gas Chromatography-Mass Spectrometry
MH  - Humans
MH  - Mephobarbital/*blood/therapeutic use
MH  - Phenobarbital/*blood
EDAT- 1979/01/01 00:00
MHDA- 1979/01/01 00:01
CRDT- 1979/01/01 00:00
PHST- 1979/01/01 00:00 [pubmed]
PHST- 1979/01/01 00:01 [medline]
PHST- 1979/01/01 00:00 [entrez]
AID - 10.1097/00007691-197901000-00012 [doi]
PST - ppublish
SO  - Ther Drug Monit. 1979;1(1):117-22. doi: 10.1097/00007691-197901000-00012.