PMID- 5545127
OWN - NLM
STAT- MEDLINE
DCOM- 19710406
LR  - 20181113
IS  - 0021-9738 (Print)
IS  - 0021-9738 (Linking)
VI  - 50
IP  - 3
DP  - 1971 Mar
TI  - Regulatory mechanisms of hemoglobin oxygen affinity in acidosis and alkalosis.
PG  - 700-6
AB  - The recent reports of the effect of 2,3-diphosphoglycerate (2,3-DPG) on 
      hemoglobin affinity for oxygen suggested that this substance may play a role in 
      man's adaptation to acidosis and alkalosis.A study of the effect of induced 
      acidosis and alkalosis on the oxyhemoglobin dissociation curve of normal man was 
      therefore carried out, and the mechanisms involved in the physiological 
      regulation of hemoglobin oxygen affinity examined.In acute changes of plasma pH 
      there was no alteration in red cell 2,3-DPG content. However, there were changes 
      in hemoglobin oxygen affinity and these correlated with changes in mean 
      corpuscular hemoglobin concentration (MCHC). With maintained acidosis and 
      alkalosis, red cell 2,3-DPG content was altered and correlated with the changes 
      in hemoglobin oxygen affinity. Both of these mechanisms shift the hemoglobin 
      oxygen dissociation curve opposite to the direct pH (Bohr) effect, and providing 
      the rate of pH change is neither too rapid nor too large, they counteract the 
      direct pH effect and the in vivo hemoglobin oxygen affinity remains unchanged. It 
      is also shown that approximately 35% of the change in hemoglobin oxygen affinity 
      resulting from an alteration in red cell 2,3-DPG, is explained by effect of 
      2,3-DPG on the red cell pH.
FAU - Bellingham, A J
AU  - Bellingham AJ
FAU - Detter, J C
AU  - Detter JC
FAU - Lenfant, C
AU  - Lenfant C
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Clin Invest
JT  - The Journal of clinical investigation
JID - 7802877
RN  - 142M471B3J (Carbon Dioxide)
SB  - IM
MH  - Acidosis/*blood
MH  - Alkalosis/*blood
MH  - Arteries
MH  - Blood
MH  - Carbon Dioxide/blood
PMC - PMC291978
EDAT- 1971/03/01 00:00
MHDA- 1971/03/01 00:01
PMCR- 1971/03/01
CRDT- 1971/03/01 00:00
PHST- 1971/03/01 00:00 [pubmed]
PHST- 1971/03/01 00:01 [medline]
PHST- 1971/03/01 00:00 [entrez]
PHST- 1971/03/01 00:00 [pmc-release]
AID - 10.1172/JCI106540 [doi]
PST - ppublish
SO  - J Clin Invest. 1971 Mar;50(3):700-6. doi: 10.1172/JCI106540.