PMID- 55986
OWN - NLM
STAT- MEDLINE
DCOM- 19760410
LR  - 20180215
IS  - 1660-8151 (Print)
IS  - 1660-8151 (Linking)
VI  - 16
IP  - 4
DP  - 1976
TI  - Immunoglobulin E in renal disease.
PG  - 256-71
AB  - Samples of renal tissue from 373 patients were examined for the presence of 
      immunoglobulin E (IgE) by immunofluorescent techniques. Only trace to ++ amounts 
      ( on a scale of ++++) were found in 20 patients: 4/9 with post-streptococcal 
      acute glomerulonephritis (GN), 5/30 with GN associated with systemic lupus 
      erythematosus, 3/20 with membranous GN, 1/4 with Goodpasture's syndrome, 2/18 
      with recurrent microhematuria and focal GN, 1/5 with hemolytic anemia and uremia, 
      3/73 with renal homografts, and 1/5 with dermatomyositis. No IgE was found in 18 
      patients with lipoid nephrosis, 8 of whom were being treated with prednisone, nor 
      in 5 patients with focal glomerular sclerosis and the nephrotic syndrome. Serum 
      IgE was measured in 9 of the 20 patients with glomerular deposits of this 
      globulin. With one exception, levels of IgE were within the range generally 
      considered to be normal. However, they were greater than the mean of this range 
      in all but two and near the highest limits of normal in most. Neither the amounts 
      of serum IgE nor the degree of proteinuria could be related to the intensity of 
      stain for IgE in the glomeruli of these patients.
FAU - Robertson, M R
AU  - Robertson MR
FAU - Potter, E V
AU  - Potter EV
FAU - Roberts, M L
AU  - Roberts ML
FAU - Patterson, R
AU  - Patterson R
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Switzerland
TA  - Nephron
JT  - Nephron
JID - 0331777
RN  - 0 (Immunoglobulin G)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 9007-36-7 (Complement System Proteins)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Child
MH  - Child, Preschool
MH  - Complement System Proteins
MH  - Female
MH  - Fluorescent Antibody Technique
MH  - Glomerulonephritis/immunology
MH  - Humans
MH  - Immunoglobulin E/*analysis
MH  - Immunoglobulin G
MH  - Kidney Diseases/*immunology
MH  - Kidney Glomerulus/*immunology
MH  - Male
MH  - Middle Aged
MH  - Staining and Labeling
EDAT- 1976/01/01 00:00
MHDA- 1976/01/01 00:01
CRDT- 1976/01/01 00:00
PHST- 1976/01/01 00:00 [pubmed]
PHST- 1976/01/01 00:01 [medline]
PHST- 1976/01/01 00:00 [entrez]
AID - 10.1159/000180610 [doi]
PST - ppublish
SO  - Nephron. 1976;16(4):256-71. doi: 10.1159/000180610.