PMID- 56029
OWN - NLM
STAT- MEDLINE
DCOM- 19760410
LR  - 20190818
IS  - 0300-9475 (Print)
IS  - 0300-9475 (Linking)
VI  - 4
IP  - 8
DP  - 1975
TI  - In vitro target cell lysis mediated by normal human lymphocytes (K cells) or 
      monocytes.
PG  - 769-76
AB  - Guinea pig IgG1 or IgG2 anti-dinitrophenyl (DNP) Antibody preparations were used 
      for induction of target cell lysis by normal human lymphocytes (K cells) or 
      monocytes. Target cells were DNP-coated 51Cr-labeled chicken erythrocytes. 
      Antibody concentrations were assayed by an ammonium sulphate precipitation 
      technique. When antiserum was obtained by immunization with the antigen in 
      Freund's complete adjuvant (FCA), IgG2 antibodies predominated and were 
      significantly more efficient inducers of K-cell-mediated lysis than IgG1 
      antibodies. The lowest activity in K-cell-mediated lysis was seen with IgG1 from 
      antiserum obtained by immunization with antigen in Freund's incomplete adjuvant. 
      When these antibody fractions were tested in monocyte-mediated erythrolysis, the 
      two IgG1 fractions were as active as the IgG2 antibodies raised with antigen 
      incorporated in FCA. The results suggest that the Fc receptors of mature human 
      blood monocytes are different from those on the effector cells in the K-cell 
      preparations.
FAU - Larsson, A
AU  - Larsson A
FAU - Ohlander, C
AU  - Ohlander C
LA  - eng
PT  - Journal Article
PL  - England
TA  - Scand J Immunol
JT  - Scandinavian journal of immunology
JID - 0323767
RN  - 0 (Epitopes)
RN  - 0 (Immunoglobulin G)
SB  - IM
MH  - Animals
MH  - *Antigen-Antibody Reactions
MH  - Binding Sites, Antibody
MH  - Cytotoxicity Tests, Immunologic
MH  - Epitopes
MH  - Guinea Pigs
MH  - *Immunoglobulin G
MH  - Lymphocytes/*immunology
MH  - Monocytes/*immunology
EDAT- 1975/01/01 00:00
MHDA- 1975/01/01 00:01
CRDT- 1975/01/01 00:00
PHST- 1975/01/01 00:00 [pubmed]
PHST- 1975/01/01 00:01 [medline]
PHST- 1975/01/01 00:00 [entrez]
AID - 10.1111/j.1365-3083.1975.tb03716.x [doi]
PST - ppublish
SO  - Scand J Immunol. 1975;4(8):769-76. doi: 10.1111/j.1365-3083.1975.tb03716.x.