PMID- 569588
OWN - NLM
STAT- MEDLINE
DCOM- 19790324
LR  - 20190623
IS  - 0014-2999 (Print)
IS  - 0014-2999 (Linking)
VI  - 52
IP  - 3-4
DP  - 1978 Dec 1
TI  - Irritable aggression and open field behavior in rats given 
      2-phenylcyclopropylamines.
PG  - 297-302
AB  - Adult male Wistar rats given an i.p. injection (3 ml/kg) of a 
      2-phenylcyclopropylamine (59 mumol/kg) were tested 3--5 h later for shock-induced 
      aggression, jump threshold, stereotypic movement, rearing and ambulation. 
      Shock-induced aggression was facilitated by trans-1-2-phenylcyclopropylamine 
      (1-TPCP) and was suppressed by trans-d-2-phenylcyclopropylamine (d-TPCP). Neither 
      drug affected jump threshold. The effects of 1-TPCP and d-TPCP on irritable 
      aggression are discussed in terms of the effects of the drugs on monoaminergic 
      mechanisms. A behavioral syndrome of increased stereotypic behavior of the 
      serotonin-dependent type as well as decreased rearing and ambulation occurred in 
      rats given d-TPCP, trans-dl-2-phenylcyclopropylamine, 
      2-(4-chlorophenyl)-cyclopropylamine and 2-(3,4-dichlorophenyl)-cyclopropylamine, 
      but not in rats given 1-TPCP, cis-dl-2-phenylcyclopropylamine, 
      2-(2-chlorophenyl)-cyclopropylamine or 2-(2,5-dichlorophenyl)-cyclopropylamine. 
      The findings suggest that the behavioral syndrome depended in part on the absence 
      of a chlorine substitution in the ortho position of the phenyl ring.
FAU - Smith, D F
AU  - Smith DF
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Eur J Pharmacol
JT  - European journal of pharmacology
JID - 1254354
RN  - 0 (Propylamines)
SB  - IM
MH  - Aggression/*drug effects
MH  - Animals
MH  - Behavior, Animal/*drug effects
MH  - Humans
MH  - Male
MH  - Motor Activity/drug effects
MH  - Propylamines/*pharmacology
MH  - Rats
MH  - Stereoisomerism
MH  - Stereotyped Behavior/drug effects
EDAT- 1978/12/01 00:00
MHDA- 1978/12/01 00:01
CRDT- 1978/12/01 00:00
PHST- 1978/12/01 00:00 [pubmed]
PHST- 1978/12/01 00:01 [medline]
PHST- 1978/12/01 00:00 [entrez]
AID - 0014-2999(78)90282-0 [pii]
AID - 10.1016/0014-2999(78)90282-0 [doi]
PST - ppublish
SO  - Eur J Pharmacol. 1978 Dec 1;52(3-4):297-302. doi: 10.1016/0014-2999(78)90282-0.