PMID- 569773
OWN - NLM
STAT- MEDLINE
DCOM- 19790313
LR  - 20181130
IS  - 0028-3835 (Print)
IS  - 0028-3835 (Linking)
VI  - 27
IP  - 1-2
DP  - 1978
TI  - Reanalysis of the preoptic afferents and efferents involved in the surge of LH, 
      FSH and prolactin release in the proestrous rat.
PG  - 74-85
AB  - In order to elucidate neural pathways concerned with the proestrous surge of LH, 
      FSH and prolactin (Prl) release, brain transection or lesion was made acutely 
      under ether anesthesia between 12.00 and 14.00 h of proestrus, and 
      electrochemical stimulation was done under anesthesia with pentobarbital sodium 
      (31.5 mg/kg b.w.) injected at 13.45 h. Transection which interrupted the 
      connection of septum (SEPT), diagonal band of Broca (DBB) and bed nucleus of 
      stria terminalis (BST) with the preoptic-suprachiasmatic area interfered with 
      ovulation and surge of release of all 3 hormones. Isolation of the basal part of 
      the suprachiasmatic area, including the suprachiasmatic nucleus (SCH), blocked 
      ovulation also. Bilateral lesions in the medial preoptic area (MPO) with 
      platinium-iridium electrode blocked ovulation and the surge of LH and Prl 
      release, but not of FSH. Lesions in the SCH blocked ovulation and the surge of 
      LH, but not of FSH and Prl. In the rat with acute isolation of the basal part of 
      the suprachiasmatic area and SCH, stimulation of the MPO failed to induce 
      ovulation and LH release, but was followed by FSH release. Prl release was not 
      inhibited as in the intact rat. When the rat had the antero-SCH cut, stimulation 
      of the SCH induced LH release but not FSH, and the inhibition on Prl release was 
      pronounced. These findings offer evidence that the limbic-forebrain inputs are 
      necessary for the preoptic integration in order to stimulate the proestrous surge 
      of LH, FSH and Prl release. Furthermore, it is possible that separate pathways 
      from the preoptic area to the medial basal hypothalamus are concerned in the 
      stimulation of individual hormones--a restricted route for LH which may pass 
      through the SCH, a diffuse one for FSH which may pass through either the SCH or 
      anterior hypothalamic area, and a relatively diffuse one for Prl which may pass 
      outside the SCH.
FAU - Kimura, F
AU  - Kimura F
FAU - Kawakami, M
AU  - Kawakami M
LA  - eng
PT  - Journal Article
PL  - Switzerland
TA  - Neuroendocrinology
JT  - Neuroendocrinology
JID - 0035665
RN  - 9002-62-4 (Prolactin)
RN  - 9002-67-9 (Luteinizing Hormone)
RN  - 9002-68-0 (Follicle Stimulating Hormone)
SB  - IM
MH  - Afferent Pathways/*physiology
MH  - Animals
MH  - Brain/*physiology
MH  - Electric Stimulation
MH  - *Estrus
MH  - Female
MH  - Follicle Stimulating Hormone/*metabolism
MH  - Luteinizing Hormone/*metabolism
MH  - Ovulation
MH  - Pregnancy
MH  - *Proestrus
MH  - Prolactin/*metabolism
MH  - Rats
EDAT- 1978/01/01 00:00
MHDA- 1978/01/01 00:01
CRDT- 1978/01/01 00:00
PHST- 1978/01/01 00:00 [pubmed]
PHST- 1978/01/01 00:01 [medline]
PHST- 1978/01/01 00:00 [entrez]
AID - 10.1159/000122801 [doi]
PST - ppublish
SO  - Neuroendocrinology. 1978;27(1-2):74-85. doi: 10.1159/000122801.