PMID- 572751
OWN - NLM
STAT- MEDLINE
DCOM- 19791024
LR  - 20190813
IS  - 0009-9260 (Print)
IS  - 0009-9260 (Linking)
VI  - 30
IP  - 4
DP  - 1979 Jul
TI  - A critical examination of the foundations of immunotherapy for cancer.
PG  - 361-9
AB  - It is argued that immunotherapy (IMTH) for cancer, as well as the theory of 
      cancer immunogenicity on which it rests, derives no secure foundation either from 
      clinical observations or from experimental study of valid animal tumour models. 
      Discouraging clinical observations include: the long history of failure of IMTH; 
      the rejection of IMTH for choriocarcinoma--a true allograft in the patient; the 
      extreme rarity of spontaneous regression, and progressive discrediting of the 
      theory of immunosurveillance; the high frequency of nodal metastasis; and the 
      failure to demonstrate a tumour-specific antigen in man. The great majority of 
      animal tumours used for experimental studies of IMTH display artefactual 
      immunogenicity associated with their mode of induction or conditions of 
      transplantation and cannot be accepted as valid models of clinical cancer. The 
      author reviews his total failure to demonstrate immunogenicity or successful IMTH 
      using a wide range of animal tumours from which known laboratory artefacts have 
      been strictly excluded. The inordinate promotion of tumour immunology and IMTH in 
      recent years is attributed to unfortunate sociological influences encouraging 
      premature assertion of clinical relevance from experimental research.
FAU - Hewitt, H B
AU  - Hewitt HB
LA  - eng
PT  - Journal Article
PL  - England
TA  - Clin Radiol
JT  - Clinical radiology
JID - 1306016
RN  - 0 (Antibodies, Neoplasm)
RN  - 0 (Carcinoembryonic Antigen)
SB  - IM
MH  - Animals
MH  - Antibodies, Neoplasm/biosynthesis
MH  - Carcinoembryonic Antigen/analysis
MH  - Choriocarcinoma/therapy
MH  - Disease Models, Animal
MH  - Female
MH  - Humans
MH  - *Immunotherapy
MH  - Lymphatic Metastasis
MH  - Mice
MH  - Neoplasm Regression, Spontaneous
MH  - Neoplasms/immunology/*therapy
MH  - Neoplasms, Experimental/immunology
MH  - Pregnancy
MH  - Rats
MH  - Uterine Neoplasms/therapy
EDAT- 1979/07/01 00:00
MHDA- 1979/07/01 00:01
CRDT- 1979/07/01 00:00
PHST- 1979/07/01 00:00 [pubmed]
PHST- 1979/07/01 00:01 [medline]
PHST- 1979/07/01 00:00 [entrez]
AID - S0009-9260(79)80209-3 [pii]
AID - 10.1016/s0009-9260(79)80209-3 [doi]
PST - ppublish
SO  - Clin Radiol. 1979 Jul;30(4):361-9. doi: 10.1016/s0009-9260(79)80209-3.